Neural tube morphogenesis in synthetic 3D microenvironments

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 44; pp. E6831 - E6839
• Main Authors: Ranga, Adrian, Girgin, Mehmet, Meinhardt, Andrea, Eberle, Dominic, Caiazzo, Massimiliano, Tanaka, Elly M., Lutolf, Matthias P.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 01.11.2016
• Series: PNAS Plus
• Subjects: Biochemistry; Biological Sciences; Chemical synthesis; Cytoskeleton; Matrix; Microenvironments; Morphogenesis; Physical Sciences; PNAS Plus; Symmetry; neural tube; development; embryonic stem cell; extracellular matrix; organoid

Three-dimensional organoid constructs serve as increasingly widespread in vitro models for development and disease modeling. Current approaches to recreate morphogenetic processes in vitro rely on poorly controllable and ill-defined matrices, thereby largely overlooking the contribution of biochemic...