Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection

• Published in: Vaccine Vol. 32; no. 51; pp. 7005 - 7013
• Main Authors: Herasimtschuk, Anna, Downey, Jocelyn, Nelson, Mark, Moyle, Graeme, Mandalia, Sundhiya, Sikut, Rein, Adojaan, Maarja, Stanescu, Ioana, Gotch, Frances, Imami, Nesrina
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05.12.2014; Elsevier; Elsevier Limited
• Subjects: Adult; AIDS Vaccines - therapeutic use; Allergy and Immunology; Anti-Retroviral Agents - therapeutic use; Antigens; Antiretroviral agents; Applied microbiology; Biological and medical sciences; CD4-positive T-lymphocytes; CD4-Positive T-Lymphocytes - immunology; Combined Modality Therapy - methods; Cytokines - analysis; Cytokines - therapeutic use; Deoxyribonucleic acid; DNA; DNA vaccine; Enzyme-Linked Immunospot Assay; Flow Cytometry; Fundamental and applied biological sciences. Psychology; granulocyte-macrophage colony-stimulating factor; Growth Hormone - therapeutic use; Growth hormones; HIV; HIV Antigens - immunology; HIV infections; HIV Infections - immunology; HIV Infections - therapy; HIV-1; hormone replacement therapy; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Immune-based therapy; Immunization; Immunophenotyping; Immunotherapy; Infections; Infectious diseases; interferon-gamma; interleukin-2; interleukin-4; Lymphocyte Activation; Lymphocytes; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Mortality; Patients; Peptides; Perforin - analysis; Plasma; Proviruses - genetics; recombinant vaccines; somatotropin; Tetanus; Treatment Outcome; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, DNA - therapeutic use; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; HIV-1; DNA vaccine; Immune-based therapy; Hormone; Immunopathology; Immunization; CD4 T lymphocyte; Immune response; HIV-1 virus; Cytokine; Retroviridae; AIDS; Genetic vaccine; Immune deficiency; Lentivirus; Infection; Virus; Chronic; Treatment; Viral disease; Human immunodeficiency virus

This randomised, open label, phase I, immunotherapeutic study investigated the effects of interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), recombinant human growth hormone (rhGH), and therapeutic immunisation (a Clade B DNA vaccine) on combination antiretroviral therapy...