An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike - Schoof, Michael; Faust, Bryan; Saunders, Reuben A.; Sangwan, Smriti; Rezelj, Veronica; Hoppe, Nick; Boone, Morgane; Billesbølle, Christian B.; Puchades, Cristina; Azumaya, Caleigh M.; Kratochvil, Huong T.; Zimanyi, Marcell; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: ACE2; Aerosols; Affinity; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - chemistry; Angiotensin-Converting Enzyme 2 - immunology; Animals; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibody Affinity; Binding; Biochem; Chlorocebus aethiops; Coronaviridae; Coronaviruses; COVID-19; Cryoelectron Microscopy; Domains; Heat treatment; Humans; Microbio; Monoclonal antibodies; Nanobodies; Neutralization; Neutralization Tests; Problem Solving; Protein Binding; Protein Stability; Proteins; Receptors; Respiratory diseases; Severe acute respiratory syndrome coronavirus 2; Single-Domain Antibodies - chemistry; Single-Domain Antibodies - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Vero Cells; Viral diseases; Yeast