Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells[S]

• Published in: Molecular & cellular proteomics Vol. 14; no. 12; pp. 3154 - 3172
• Main Authors: Villar, Margarita, Ayllón, Nieves, Alberdi, Pilar, Moreno, Andrés, Moreno, María, Tobes, Raquel, Mateos-Hernández, Lourdes, Weisheit, Sabine, Bell-Sakyi, Lesley, de la Fuente, José
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015; The American Society for Biochemistry and Molecular Biology
• Subjects: Anaplasma phagocytophilum; Anaplasma phagocytophilum - physiology; Animals; Cell Line; Ehrlichiosis - genetics; Ehrlichiosis - metabolism; Ehrlichiosis - veterinary; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum - metabolism; Glucose - metabolism; Host-Pathogen Interactions; Ixodes scapularis; Ixodidae; Metabolic Networks and Pathways; Metabolomics - methods; Proteomics - methods; Systems Biology - methods; Ticks - microbiology

Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcr...