Structural and kinetic aspects of chemical reactions in DNA duplexes. Information on DNA local structure obtained from chemical ligation data

• Published in: Nucleic acids research Vol. 19; no. 11; pp. 3073 - 3080
• Main Authors: DOLINNAYA, N. G, TSYTOVICH, A. V, SERGEEV, V. N, ORETSKAYA, T. S, SHABAROVA, Z. A
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 11.06.1991
• Subjects: Analytical, structural and metabolic biochemistry; Autoradiography; Base Sequence; Biological and medical sciences; Carbodiimides - chemistry; DNA - chemistry; Dna, deoxyribonucleoproteins; Electrophoresis, Polyacrylamide Gel; Fundamental and applied biological sciences. Psychology; Kinetics; Molecular Sequence Data; Nucleic Acid Heteroduplexes - chemistry; Nucleic acids; Molecular hybridization; Double helical structure; Molecular structure; Oligonucleotide; Kinetics; Oligodeoxyribonucleotide; Duplex; Conformation

Chemical ligation of oligonucleotides in double-stranded helices has been considered in its structural-kinetic aspect. A study was made of (i) two series of DNA duplexes with various arrangements of reacting groups in the ligation junction induced by mispairing or by alteration of furanose structure...