Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

• Published in: Nature chemistry Vol. 7; no. 7; pp. 597 - 603
• Main Authors: Tonga, Gulen Yesilbag, Jeong, Youngdo, Duncan, Bradley, Mizuhara, Tsukasa, Mout, Rubul, Das, Riddha, Kim, Sung Tae, Yeh, Yi-Cheun, Yan, Bo, Hou, Singyuk, Rotello, Vincent M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2015; Nature Publishing Group
• Subjects: 639/638/541; 639/638/77/603; 639/925/352; 639/925/357/354; Analytical Chemistry; Biochemistry; Biomimetics; Catalysis; Chemistry; Chemistry/Food Science; Fabrication; HeLa Cells; Humans; Inorganic Chemistry; Metal Nanoparticles - chemistry; Organic Chemistry; Physical Chemistry; Transition Elements - chemistry

Bioorthogonal catalysis broadens the functional possibilities of intracellular chemistry. Effective delivery and regulation of synthetic catalytic systems in cells are challenging due to the complex intracellular environment and catalyst instability. Here, we report the fabrication of protein-sized...