Influenza A surface glycosylation and vaccine design

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 2; pp. 280 - 285
• Main Authors: Wu, Chung-Yi, Lin, Chih-Wei, Tsai, Tsung-I, Lee, Chang-Chun David, Chuang, Hong-Yang, Chen, Jhih-Bin, Tsai, Ming-Hung, Chen, Bo-Rui, Lo, Pei-Wen, Liu, Chiu-Ping, Shivatare, Vidya S., Wong, Chi-Huey
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.01.2017
• Subjects: Biological Sciences; Glycoproteins; Glycosylation; Immune response; Influenza; Influenza A virus; Orthomyxoviridae; Physical Sciences; T cell receptors; Vaccines; Viruses; glycosylation; vaccine design; influenza A virus

We have shown that glycosylation of influenza A virus (IAV) hemagglutinin (HA), especially at position N-27, is crucial for HA folding and virus survival. However, it is not known whether the glycosylation of HA and the other two major IAV surface glycoproteins, neuraminidase (NA) and M2 ion channel...