Parkin Regulates the Activity of Pyruvate Kinase M2

• Published in: The Journal of biological chemistry Vol. 291; no. 19; pp. 10307 - 10317
• Main Authors: Liu, Kun, Li, Fanzhou, Han, Haichao, Chen, Yue, Mao, Zebin, Luo, Jianyuan, Zhao, Yingming, Zheng, Bin, Gu, Wei, Zhao, Wenhui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.05.2016; American Society for Biochemistry and Molecular Biology
• Subjects: Cell Line; Glucose - genetics; Glucose - metabolism; Glycolysis; Humans; parkin; Parkinson disease; Parkinson Disease - enzymology; Parkinson Disease - genetics; Parkinson Disease - pathology; pyruvate kinase; Pyruvate Kinase - chemistry; Pyruvate Kinase - genetics; Pyruvate Kinase - metabolism; pyruvate kinase M2; Signal Transduction; Ubiquitin-Protein Ligases - chemistry; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; ubiquitylation (ubiquitination); Parkinson disease; ubiquitylation (ubiquitination); parkin; glycolysis; pyruvate kinase; pyruvate kinase M2

Parkin, a ubiquitin E3 ligase, is mutated in most cases of autosomal recessive early onset Parkinson disease. It was discovered that Parkin is also mutated in glioblastoma and other human malignancies and that it inhibits tumor cell growth. Here, we identified pyruvate kinase M2 (PKM2) as a unique s...