In vitro metabolism of cathinone positional isomers: does sex matter?

• Published in: Analytical and bioanalytical chemistry Vol. 415; no. 22; pp. 5403 - 5420
• Main Authors: Che, Peng, Davidson, J. Tyler, Still, Kristina, Kool, Jeroen, Kohler, Isabelle
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2023; Springer; Springer Nature B.V
• Subjects: Alkaloids; Analytical Chemistry; Biochemistry; Biotransformation; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Females; Food Science; Identification and classification; Isomers; Laboratory Medicine; Liquid chromatography; Liver; Males; Mass spectrometry; Mass spectroscopy; Metabolic pathways; Metabolism; Metabolites; Methods; Microsomes; Monitoring/Environmental Analysis; Monoamines; Properties; Public health; Relative abundance; Research Paper; Sex; Toxicology; Xenobiotics; United States; Netherlands; Synthetic cathinones; In vitro metabolism; Sex-specific differences; Positional isomers; Methylmethcathinones

Synthetic cathinones, one of the most prevalent categories of new psychoactive substances, have been posing a serious threat to public health. Methylmethcathinones (MMCs), notably 3-MMC, have seen an alarming increase in their use in the last decade. The metabolism and toxicology of a large majority...