4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment

• Published in: BMC genomics Vol. 25; no. 1; pp. 415 - 12
• Main Authors: Xu, Zhaokai, Wu, Yubo, Mao, Jianbo, Chen, Yiqi, Chen, Huan, Zhang, Shian, Yu, Jiafeng, Deng, Xinyi, Shen, Lijun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.04.2024; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; 4D label-free; AKT protein; Analysis; Animal models; Animals; Anti-VEGF therapy; Biomarkers; Chromatography, Liquid; Disease; Disease Models, Animal; DNA biosynthesis; DNA replication; Gene Ontology; Genes; Genomes; Growth factors; Health aspects; Labels; Lasers; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolism; Metabolites; Mice; Molecular modelling; Newborn babies; Nucleic acids; Oxygen; Oxygen - metabolism; Oxygen-induced retinopathy; Pathogenesis; Physiology; Premature babies; Premature birth; Prevention; Protein interaction; Proteins; Proteomic; Proteomics; Proteomics - methods; Retina; Retina - drug effects; Retina - metabolism; Retina - pathology; Retinopathy; Retinopathy of prematurity; Retinopathy of Prematurity - drug therapy; Retinopathy of Prematurity - metabolism; Risk factors; Signal transduction; Signal Transduction - drug effects; Statistical analysis; Tandem Mass Spectrometry; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; China; Retinopathy of prematurity; Anti-VEGF therapy; Oxygen-induced retinopathy; 4D label-free; Proteomic

Oxygen-induced retinopathy (OIR) animal model is widely used for retinopathy of prematurity (ROP) researches. The purpose of this study was to identify proteins and related pathways of OIR with or without anti-vascular endothelial growth factor (VEGF) treatment, for use as biomarkers in diagnosing a...