The Exocyst Complex Associates with Microtubules to Mediate Vesicle Targeting and Neurite Outgrowth

• Published in: The Journal of neuroscience Vol. 21; no. 11; pp. 3839 - 3848
• Main Authors: Vega, Irving E, Hsu, Shu-Chan
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 01.06.2001; Society for Neuroscience
• Subjects: Animals; Brain Chemistry; Calcium-Binding Proteins; Cell Differentiation - physiology; Cells, Cultured; Enzyme Inhibitors - pharmacology; Exocyst complex; Exocytosis - physiology; Growth Cones - metabolism; Growth Cones - ultrastructure; Hippocampus - cytology; Hippocampus - metabolism; Macromolecular Substances; MAP Kinase Signaling System - drug effects; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred BALB C; Microtubule-Organizing Center - metabolism; Microtubules - chemistry; Microtubules - drug effects; Microtubules - metabolism; Nerve Growth Factor - pharmacology; Nerve Tissue Proteins - metabolism; Neurites - metabolism; Neurites - ultrastructure; Neurons - metabolism; Neurons - ultrastructure; PC12 Cells; Precipitin Tests; Protein Synthesis Inhibitors - pharmacology; Rats; Secretory Vesicles - metabolism; Synaptotagmins

During neuronal development, vesicles are targeted to the growth cone to promote neurite outgrowth and synaptogenesis. The Exocyst complex is an essential macromolecule in the secretory pathway that may play a role in vesicle targeting. Although it has been shown that this complex is enriched in rat...