Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 20; pp. 5592 - 5597
• Main Authors: Yeh, Shih-Chi, Wang, Pao-Yuan, Lou, Yi-Wei, Khoo, Kay-Hooi, Hsiao, Michael, Hsu, Tsui-Ling, Wong, Chi-Huey
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.05.2016
• Subjects: AC133 Antigen - analysis; Animals; Biological Sciences; Brain cancer; Brain Neoplasms - pathology; Cell Line, Tumor; Cytotoxicity; G(M1) Ganglioside - analysis; Gangliosides - analysis; Gangliosides - physiology; Glioblastoma - chemistry; Glioblastoma - etiology; Glioblastoma - pathology; Humans; Mice; Neoplastic Stem Cells - chemistry; Proto-Oncogene Proteins c-met - metabolism; Sialyltransferases - analysis; Sialyltransferases - physiology; Stem cells; Tumors; gangliosides; GBM; cancer stem cells; ST8SIA1; glycosphingolipids

The cancer stem cells (CSCs) of glioblastoma multiforme (GBM), a grade IV astrocytoma, have been enriched by the expressed marker CD133. However, recent studies have shown that CD133⁻ cells also possess tumor-initiating potential. By analysis of gangliosides on various cells, we show that gangliosid...