Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen–Glucose Deprivation-Induced Ischemic Neuronal Injury

• Published in: International journal of nanomedicine Vol. 16; pp. 3661 - 3678
• Main Authors: Wang, Da-Peng, Jin, Kai-Yan, Zhao, Peng, Lin, Qi, Kang, Kai, Hai, Jian
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Amidohydrolases - antagonists & inhibitors; Amidohydrolases - metabolism; Analysis; Angiogenesis; Animals; Antibodies; Apoptosis - drug effects; Apoptosis - physiology; Benzamides - pharmacology; Brain damage; brain ischemia; Brain Ischemia - drug therapy; Brain Ischemia - metabolism; Brain Ischemia - pathology; cannabinoid receptor; Carbamates - pharmacology; Cells, Cultured; Contact angle; Dextrose; Endocannabinoids - metabolism; Enzymes; fatty-acid amide hydrolase; Fourier transforms; Glucose; Glucose - metabolism; Hippocampus - drug effects; Hippocampus - pathology; Homeostasis; Hydrolases; Ischemia; Membranes; Membranes, Artificial; mitochondrial oxidative stress; nanofiber; Nanofibers - chemistry; Nanostructured materials; Nervous system diseases; Neurogenesis; Neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents - pharmacology; Original Research; Oxidative stress; Oxygen - metabolism; Rats; Rats, Sprague-Dawley; Spinal cord injuries; Stroke; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - chemistry; Vascular Endothelial Growth Factor A - pharmacology; vegf-a; Japan; China; St Louis Missouri; United States > US; fatty-acid amide hydrolase; brain ischemia; VEGF-A; cannabinoid receptor; mitochondrial oxidative stress; nanofiber

Brain ischemia is a common neurological disorder worldwide that activates a cascade of pathophysiological events involving decreases in oxygen and glucose levels. Despite substantial efforts to explore its pathogenesis, the management of ischemic neuronal injury remains an enormous challenge. Accumu...