Interactions between host and gut microbiota in gestational diabetes mellitus and their impacts on offspring

• Published in: BMC microbiology Vol. 24; no. 1; pp. 161 - 17
• Main Authors: Wang, Shuxian, Cui, Zifeng, Yang, Huixia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.05.2024; BioMed Central; BMC
• Subjects: Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - metabolism; Biosynthesis; Diabetes; Diabetes in pregnancy; Diabetes mellitus; Diabetes, Gestational - metabolism; Diabetes, Gestational - microbiology; Dysbacteriosis; Dysbiosis - microbiology; Fatty Acids, Volatile - metabolism; Feces; Female; Fetuses; Gastrointestinal Microbiome; Gestational diabetes mellitus (GDM); Glucose; Gut microbiota; Health aspects; High density lipoprotein; Host Microbial Interactions; Host-microbiome interactions; Humans; Infants (Newborn); Inflammation; Insulin resistance; Intestinal microflora; Lipopolysaccharides; Lipopolysaccharides - metabolism; Metabolic disorders; Metabolism; Metabolites; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Obesity; Obstetrical research; Offspring; Pediatric research; Physiological aspects; Physiology; Pregnancy; Pregnancy complications; TLR4 protein; Toll-like receptors; Weight control; China; Gut microbiota; Gestational diabetes mellitus (GDM); Offspring; Host-microbiome interactions; Metabolism

Gestational diabetes mellitus (GDM) is characterized by insulin resistance and low-grade inflammation, and most studies have demonstrated gut dysbiosis in GDM pregnancies. Overall, they were manifested as a reduction in microbiome diversity and richness, depleted short chain fatty acid (SCFA)-produc...