Meta-analysis of 24-Hour Intraocular Pressure Studies Evaluating the Efficacy of Glaucoma Medicines

• Published in: Ophthalmology (Rochester, Minn.) Vol. 115; no. 7; pp. 1117 - 1122.e1
• Main Authors: Stewart, William C., MD, Konstas, Anastasios G.P., MD, PhD, Nelson, Lindsay A., BS, Kruft, Bonnie, BS
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2008; Elsevier
• Subjects: Amides - administration & dosage; Antihypertensive Agents - administration & dosage; Bimatoprost; Biological and medical sciences; Circadian Rhythm - drug effects; Circadian Rhythm - physiology; Cloprostenol - administration & dosage; Cloprostenol - analogs & derivatives; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Exfoliation Syndrome - drug therapy; Exfoliation Syndrome - physiopathology; Glaucoma and intraocular pressure; Glaucoma, Open-Angle - drug therapy; Glaucoma, Open-Angle - physiopathology; Humans; Intraocular Pressure - drug effects; Intraocular Pressure - physiology; Medical sciences; Miscellaneous; Ocular Hypertension - drug therapy; Ocular Hypertension - physiopathology; Ophthalmic Solutions - administration & dosage; Ophthalmology; Prostaglandins F, Synthetic - administration & dosage; Randomized Controlled Trials as Topic; Single-Blind Method; Sulfonamides - administration & dosage; Thiophenes - administration & dosage; Timolol - administration & dosage; Tonometry, Ocular; Travoprost; Treatment Outcome; Glaucoma; Medicine; Protozoa; Eye disease; Glaucoma (eye); Ciliata; Ophthalmology; Metaanalysis; Intraocular pressure

Purpose To evaluate efficacy and safety data of currently available ocular hypotensive medicines derived from 24-hour studies, of similar design, in patients with primary open-angle glaucoma (POAG), exfoliative glaucoma, or ocular hypertension (OH). Design Meta-analysis of published articles evaluat...