GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction - Zhang, Qin; Yuan, Xi; Luan, Xiaojin; Lei, Ting; Li, Yiran; Chu, Wei; Yao, Qi; Baker, Philip N.; Qi, Hongbo; Li, Hui (Molecular medicine (Cambridge, Mass.), 2024)
Keywords: Acetyl-CoA Carboxylase - metabolism; Adult; AMP-Activated Protein Kinases - metabolism; AMPK/ACC pathway; Animals; Antioxidants; Cell culture; Cell Line; Diabetes, Gestational - metabolism; Disease Models, Animal; Female; Ferroptosis; Fetal growth restriction; Fetal Growth Retardation - etiology; Fetal Growth Retardation - metabolism; Fetal Growth Retardation - pathology; Gestational diabetes; Gestational diabetes mellitus; Glucose; Glucose Transporter Type 1 - genetics; Glucose Transporter Type 1 - metabolism; GLUT1; Humans; Kinases; Laboratory animals; Lipid Metabolism; Lipids; Metabolism; Mice; Oxidative stress; Pathophysiology; Phosphorylation; Placenta - metabolism; Pregnancy; Trophoblasts - metabolism; United States--US; AMPK/ACC pathway; Gestational diabetes mellitus; GLUT1; Ferroptosis; Fetal growth restriction