Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy

• Published in: International journal of nanomedicine Vol. 14; pp. 1533 - 1549
• Main Authors: Lee, Pei-Chi, Zan, Bo-Shen, Chen, Li-Ting, Chung, Tze-Wen
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2019; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Amines - chemistry; Animals; anticoagulant; Anticoagulants; Anticoagulants (Medicine); Anticoagulants - pharmacology; antioxidant; Antioxidants; Antioxidants - pharmacology; Biomedical materials; Blood clot; Cell Hypoxia - drug effects; Cell Line; Delayed-Action Preparations - pharmacology; Drug Delivery Systems; Drug Liberation; Drugs; Glutathione; Glutathione - chemistry; heparin; human bone marrow mesenchymal stem cells (hBMSCs); Human Umbilical Vein Endothelial Cells - drug effects; Humans; Hyaluronic acid; Hyaluronic Acid - chemistry; Hydrogen Peroxide - metabolism; Injuries; Ischemia; ischemia/reperfusion (I/R); Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mice; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Original Research; Oxidative stress; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; Scientific equipment and supplies industry; Stem cells; Superoxides - metabolism; Thrombosis; Tissue engineering; Transplantation; Vehicles; United States; Germany; Taiwan; heparin; antioxidant; glutathione; human bone marrow mesenchymal stem cells; anticoagulant; I/R; reperfusion; hBMSCs; ischemia

Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H O and leads to vascular thrombosis, which causes tissue damage. In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy....