Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy
Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H O and leads to vascular thrombosis, which causes tissue damage. In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy....
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| Published in | International journal of nanomedicine Vol. 14; pp. 1533 - 1549 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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New Zealand
Dove Medical Press Limited
01.01.2019
Taylor & Francis Ltd Dove Medical Press |
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| Abstract | Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H
O
and leads to vascular thrombosis, which causes tissue damage.
In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy.
Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions.
The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H
O
-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H
O
in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake.
We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs. |
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| AbstractList | Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H
O
and leads to vascular thrombosis, which causes tissue damage.
In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy.
Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions.
The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H
O
-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H
O
in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake.
We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs. Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which causes tissue damage. Purpose: In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy. Methods: Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions. Results: The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H2O2-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H2O2 in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake. Conclusion: We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs. Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which causes tissue damage.BACKGROUNDIschemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which causes tissue damage.In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy.PURPOSEIn this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy.Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions.METHODSBoth heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions.The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H2O2-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H2O2 in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake.RESULTSThe drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H2O2-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H2O2 in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake.We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs.CONCLUSIONWe propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs. Pei-Chi Lee,1 Bo-Shen Zan,1 Li-Ting Chen,1 Tze-Wen Chung1,2 1Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan; 2Drug Delivery Department, Center for Advanced Pharmaceutics and Drug Delivery Research, National Yang Ming University, Taipei 112, Taiwan Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which causes tissue damage. Purpose: In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy. Methods: Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions. Results: The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H2O2-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H2O2 in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake. Conclusion: We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs. Keywords: ischemia/reperfusion, I/R, heparin, glutathione, anticoagulant, antioxidant, human bone marrow mesenchymal stem cells, hBMSCs Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as [H.sub.2][O.sub.2] and leads to vascular thrombosis, which causes tissue damage. Purpose: In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy. Methods: Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions. Results: The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An [H.sub.2][O.sub.2]-responsive platform is also developed by combining silk fibroin and horse peroxidase to detect [H.sub.2][O.sub.2] in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake. Conclusion: We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs. Keywords: ischemia/reperfusion, I/R, heparin, glutathione, anticoagulant, antioxidant, human bone marrow mesenchymal stem cells, hBMSCs |
| Audience | Academic |
| Author | Lee, Pei-Chi Zan, Bo-Shen Chen, Li-Ting Chung, Tze-Wen |
| AuthorAffiliation | 1 Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan, twchung@ym.edu.tw 2 Drug Delivery Department, Center for Advanced Pharmaceutics and Drug Delivery Research, National Yang Ming University, Taipei 112, Taiwan, twchung@ym.edu.tw |
| AuthorAffiliation_xml | – name: 1 Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan, twchung@ym.edu.tw – name: 2 Drug Delivery Department, Center for Advanced Pharmaceutics and Drug Delivery Research, National Yang Ming University, Taipei 112, Taiwan, twchung@ym.edu.tw |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30880963$$D View this record in MEDLINE/PubMed |
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| Keywords | heparin antioxidant glutathione human bone marrow mesenchymal stem cells anticoagulant I/R reperfusion hBMSCs ischemia |
| Language | English |
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| Snippet | Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H
O
and leads to vascular thrombosis, which causes tissue damage.
In this... Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as [H.sub.2][O.sub.2] and leads to vascular thrombosis, which causes... Background: Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which causes tissue damage.... Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which causes tissue... Pei-Chi Lee,1 Bo-Shen Zan,1 Li-Ting Chen,1 Tze-Wen Chung1,2 1Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan; 2Drug... |
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| SubjectTerms | Amines - chemistry Animals anticoagulant Anticoagulants Anticoagulants (Medicine) Anticoagulants - pharmacology antioxidant Antioxidants Antioxidants - pharmacology Biomedical materials Blood clot Cell Hypoxia - drug effects Cell Line Delayed-Action Preparations - pharmacology Drug Delivery Systems Drug Liberation Drugs Glutathione Glutathione - chemistry heparin human bone marrow mesenchymal stem cells (hBMSCs) Human Umbilical Vein Endothelial Cells - drug effects Humans Hyaluronic acid Hyaluronic Acid - chemistry Hydrogen Peroxide - metabolism Injuries Ischemia ischemia/reperfusion (I/R) Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mice Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Original Research Oxidative stress Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Scientific equipment and supplies industry Stem cells Superoxides - metabolism Thrombosis Tissue engineering Transplantation Vehicles |
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| Title | Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy |
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