Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae - Zhang, Xiaolin; Song, Jiankang; Klymov, Alexey; Zhang, Yang; de Boer, Leonie; Jansen, John; van den Beucken, Jeroen; Yang, Fang; Zaat, Sebastian; Leeuwenburgh, Sander (International journal of nanomedicine, 2018)
Keywords: Additives; Animal genetic engineering; Animals; Antibacterial agents; Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; bio-distribution; Biological products; Biomedical materials; Care and treatment; cell-material interaction; Drug Delivery Systems; Embryos; Endocytosis - drug effects; Express delivery services; Fluorescence; Fluorescence microscopy; Fluorescent Dyes - metabolism; Gelatin - chemistry; Genetic engineering; Green Fluorescent Proteins - metabolism; Health aspects; Humans; Immune system; in vivo real-time monitoring; Infection; Injections, Intramuscular; Injections, Intravenous; intracellular infection; Larva - cytology; Larva - drug effects; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Medical research; Microscopy; Nanoparticles; Nanospheres - chemistry; Nanospheres - ultrastructure; Original Research; Osteomyelitis; Pathogens; Polymers; Staphylococcal infections; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus infections; Staphylococcus infections; Survival Analysis; Tissue Distribution; Vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacology; Zebrafish; Zebrafish - metabolism; Zebrafish - microbiology; Netherlands; biodistribution; in vivo real-time monitoring; intracellular infection; cell-material interaction; fluorescence microscopy; Staphylococcus aureus