Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 150; no. 4; pp. 875 - 887.e9
• Main Authors: Wouters, Mira M., Balemans, Dafne, Van Wanrooy, Sander, Dooley, James, Cibert-Goton, Vincent, Alpizar, Yeranddy A., Valdez-Morales, Eduardo E., Nasser, Yasmin, Van Veldhoven, Paul P., Vanbrabant, Winde, Van der Merwe, Schalk, Mols, Raf, Ghesquière, Bart, Cirillo, Carla, Kortekaas, Inge, Carmeliet, Peter, Peetermans, Willy E., Vermeire, Séverine, Rutgeerts, Paul, Augustijns, Patrick, Hellings, Peter W., Belmans, Ann, Vanner, Stephen, Bulmer, David C., Talavera, Karel, Vanden Berghe, Pieter, Liston, Adrian, Boeckxstaens, Guy E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2016
• Subjects: Abdominal Pain - metabolism; Abdominal Pain - physiopathology; Abdominal Pain - prevention & control; Adolescent; Adult; Aged; Analgesics - adverse effects; Analgesics - therapeutic use; Belgium; Biopsy; Butyrophenones - adverse effects; Butyrophenones - therapeutic use; Calcium Signaling - drug effects; Double-Blind Method; Drug; Female; Gastroenterology and Hepatology; Gastrointestinal Agents - adverse effects; Gastrointestinal Agents - therapeutic use; Histamine H1 Antagonists - adverse effects; Histamine H1 Antagonists - therapeutic use; Humans; Irritable Bowel Syndrome - diagnosis; Irritable Bowel Syndrome - drug therapy; Irritable Bowel Syndrome - metabolism; Irritable Bowel Syndrome - physiopathology; Male; Middle Aged; Neurons - drug effects; Neurons - metabolism; Pain Measurement; Pain Threshold - drug effects; Piperidines - adverse effects; Piperidines - therapeutic use; Quality of Life; Receptor Cross-Talk - drug effects; Receptors, Histamine H1 - drug effects; Receptors, Histamine H1 - metabolism; Rectum - innervation; Remission Induction; Sensory Neurons; Surveys and Questionnaires; Time Factors; Transient Receptor Potential Cation Channel Subfamily V Member 1; Treatment; Treatment Outcome; TRPV Cation Channels - metabolism; Young Adult; Belgium; Sensory Neurons; Drug; Transient Receptor Potential Cation Channel Subfamily V Member 1; HRH1; Treatment; Ca2; DRG; mRNA; IBS; TRPV1; HV; calcium; irritable bowel syndrome; dorsal root ganglia; healthy volunteer; Ca 2; histamine receptor H1; transient reporter potential channel V1; messenger RNA

Histamine sensitizes the nociceptor transient reporter potential channel V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We investigated the role of TRPV1 in irritable bowel syndrome (IBS) and evaluated if an antagonist of histamine receptor H1 (HRH1) could reduc...