Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome - Wouters, Mira M.; Balemans, Dafne; Van Wanrooy, Sander; Dooley, James; Cibert-Goton, Vincent; Alpizar, Yeranddy A.; Valdez-Morales, Eduardo E.; Nasser, Yasmin; Van Veldhoven, Paul P.; Vanbrabant, Winde; Van der Merwe, Schalk; Mols, Raf; et al. (Gastroenterology (New York, N.Y. 1943), 2016)
Keywords: Abdominal Pain - metabolism; Abdominal Pain - physiopathology; Abdominal Pain - prevention & control; Adolescent; Adult; Aged; Analgesics - adverse effects; Analgesics - therapeutic use; Belgium; Biopsy; Butyrophenones - adverse effects; Butyrophenones - therapeutic use; Calcium Signaling - drug effects; Double-Blind Method; Drug; Female; Gastroenterology and Hepatology; Gastrointestinal Agents - adverse effects; Gastrointestinal Agents - therapeutic use; Histamine H1 Antagonists - adverse effects; Histamine H1 Antagonists - therapeutic use; Humans; Irritable Bowel Syndrome - diagnosis; Irritable Bowel Syndrome - drug therapy; Irritable Bowel Syndrome - metabolism; Irritable Bowel Syndrome - physiopathology; Male; Middle Aged; Neurons - drug effects; Neurons - metabolism; Pain Measurement; Pain Threshold - drug effects; Piperidines - adverse effects; Piperidines - therapeutic use; Quality of Life; Receptor Cross-Talk - drug effects; Receptors, Histamine H1 - drug effects; Receptors, Histamine H1 - metabolism; Rectum - innervation; Remission Induction; Sensory Neurons; Surveys and Questionnaires; Time Factors; Transient Receptor Potential Cation Channel Subfamily V Member 1; Treatment; Treatment Outcome; TRPV Cation Channels - metabolism; Young Adult; Belgium; Sensory Neurons; Drug; Transient Receptor Potential Cation Channel Subfamily V Member 1; HRH1; Treatment; Ca2; DRG; mRNA; IBS; TRPV1; HV; calcium; irritable bowel syndrome; dorsal root ganglia; healthy volunteer; Ca 2; histamine receptor H1; transient reporter potential channel V1; messenger RNA