Nerve guidance conduit with a hybrid structure of a PLGA microfibrous bundle wrapped in a micro/nanostructured membrane

• Published in: International journal of nanomedicine Vol. 12; pp. 421 - 432
• Main Authors: Peng, Shih-Wen, Li, Ching-Wen, Chiu, Ing-Ming, Wang, Gou-Jen
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Acids; Animals; Biomedical materials; Biopolymers; Cell adhesion & migration; Cell growth; Cell Movement; Cell Proliferation; Cells, Cultured; Guided Tissue Regeneration - methods; Health aspects; Hydrogels; Injuries; Lactic Acid - chemistry; Medical research; Membranes, Artificial; Mice; micro/nanostructured; microfibrous; Nanostructures - chemistry; Nanotechnology; nerve guidance conduit; Nerve regeneration; Nerve Regeneration - physiology; Original Research; PLGA; Polyglycolic Acid - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Stem cells; Technology application; Tissue engineering; Tissue Scaffolds; microfibrous; micro/nanostructured; nerve regeneration; PLGA; nerve guidance conduit

Nerve repair in tissue engineering involves the precise construction of a scaffold to guide nerve cell regeneration in the desired direction. However, improvements are needed to facilitate the cell migration/growth rate of nerves in the center of a nerve conduit. In this paper, we propose a nerve gu...