Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation

• Published in: International journal of nanomedicine Vol. 14; pp. 4767 - 4780
• Main Authors: Chiu, Chien-Yu, Chung, Tze-Wen, Chen, Si-Yi, Ma, Yunn-Hwa
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2019; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Adsorption; Animals; Biomedical materials; Blood; Dextrans; Dextrans - chemistry; Drugs; Endothelium; Flow (Dynamics); Glycols (Class of compounds); Hemodynamics; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Laboratory animals; Magnetic Fields; magnetic nanoparticles; magnetic targeting; Magnetite Nanoparticles - chemistry; microcirculation; Microcirculation - physiology; Microvessels - physiology; Nanocomposites; Nanoparticles; Original Research; Polyethylene glycol; Polyethylene Glycols - chemistry; Polymers; Polyols; Polysaccharides; Proteins; Rats, Sprague-Dawley; Static Electricity; Taiwan; United States > US; Germany; polyethylene glycol; magnetic targeting; magnetic nanoparticles; microcirculation; hemodynamics

Magnetic nanoparticles (MNPs) can be localized against hemodynamic forces in blood vessels with the application of an external magnetic field. In addition, PEGylation of nanoparticles may increase the half-life of nanocomposites in circulation. In this work, we examined the effect of PEGylation on t...