Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes

• Published in: Diabetes care Vol. 29; no. 8; pp. 1826 - 1832
• Main Authors: Martin, Julie, Wang, Zhong Q, Zhang, Xian H, Wachtel, Deborah, Volaufova, Julia, Matthews, Dwight E, Cefalu, William T
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2006
• Subjects: abdominal fat; Adipose Tissue; Adipose Tissue - drug effects; Adult; Aged; Agents; Biological and medical sciences; blood glucose; Chromium; Chromium (Nutrient); Clinical medicine; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diet therapy; Dietary supplements; Disease control; drug effects; drug therapy; Drug Therapy, Combination; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Environmental health; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; free fatty acids; gastrointestinal system; glipizide; glucose; glycemic control; Health aspects; Humans; Insulin; Insulin - therapeutic use; insulin resistance; lean body mass; Male; Medical sciences; Medical treatment; Metabolism; Middle Aged; noninsulin-dependent diabetes mellitus; Patients; pharmacology; Phenotype; physiopathology; Picolinic Acids; Picolinic Acids - pharmacology; therapeutic use; Type 2 diabetes; visceral fat; weight gain; Weight Gain - drug effects; United States; Endocrinopathy; Type 2 diabetes; Human; Pancreatic hormone; Sensitivity; Body weight; Chromium; Metabolic diseases; Supplementation; Insulin; Weight gain; Pyridine derivatives

OBJECTIVE:--Chromium picolinate (CrPic) supplementation has been suggested to improve glycemia, but there are conflicting reports on efficacy. We sought to determine the effect of CrPic on insulin sensitivity, glycemic control, and body composition in subjects with type 2 diabetes. RESEARCH DESIGN A...