Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat

• Published in: Psychopharmacology Vol. 233; no. 6; pp. 949 - 960
• Main Authors: Yohn, Samantha E., Lopez-Cruz, Laura, Hutson, Peter H., Correa, Merce, Salamone, John D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2016; Springer; Springer Nature B.V
• Subjects: Animal behavior; Animals; Behavior, Animal - drug effects; Biomedical and Life Sciences; Biomedicine; Choice Behavior - drug effects; Citalopram; Citalopram - pharmacology; Dopamine; Dosage and administration; Drug Interactions; Feeding Behavior - drug effects; Lisdexamfetamine; Lisdexamfetamine Dimesylate - pharmacology; Male; Motivation - drug effects; Neurosciences; Observations; Original Investigation; Pharmacology/Toxicology; Psychiatry; Psychopharmacology; Psychotropic drugs; Rats; Rats, Sprague-Dawley; Reward; Rodents; Serotonin Uptake Inhibitors - pharmacology; SSRI; Fatigue; Dopamine; Motivation; Decision making; Behavioral activation

Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, including serotonin transport (SERT) inhibitors. Objectives Tests of effort-based...