Working memory deficits in neuronal nitric oxide synthase knockout mice: Potential impairments in prefrontal cortex mediated cognitive function

• Published in: Biochemical and biophysical research communications Vol. 408; no. 4; pp. 707 - 712
• Main Authors: Zoubovsky, Sandra P., Pogorelov, Vladimir M., Taniguchi, Yu, Kim, Sun-Hong, Yoon, Peter, Nwulia, Evaristus, Sawa, Akira, Pletnikov, Mikhail V., Kamiya, Atsushi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.05.2011
• Subjects: Animals; Axonogenesis; Body Weight - genetics; Brain; Carrier Proteins - metabolism; Cell Nucleus - metabolism; Central nervous system; cerebral cortex; Cognition; Cognitive ability; Conditioning, Psychological; Cortex; Cortex (prefrontal); Cyclic GMP; DISC1; DISC1 protein; Fear; Fear conditioning; fearfulness; genes; Guanylate cyclase; human genetics; Hyperactivity; knockout mutants; Memory; Memory Disorders - genetics; Memory, Short-Term; Mental disorders; Mice; Mice, Knockout; Nerve Tissue Proteins - metabolism; neuronal nitric oxide synthase; Nitric oxide; Nitric Oxide Synthase Type I - genetics; Nitric-oxide synthase; nNOS; Prefrontal cortex; Prefrontal Cortex - enzymology; Prefrontal Cortex - physiopathology; protein binding; proteins; Recognition, Psychology; Risk factors; Schizophrenia; Short term memory; Signal transduction; Working memory; Schizophrenia; Cognition; Working memory; Prefrontal cortex; DISC1; nNOS

► nNOS knockout mice exhibit mild impairments in object recognition memory. ► nNOS knockout mice display working memory deficits, potential impairments in prefrontal cortical functioning. ► nNOS interacts with DISC1, another genetic risk factor for schizophrenia that plays roles for cortical develop...