Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 19; pp. 5447 - 5452
• Main Authors: Deng, Xian, Lu, Tiancong, Wang, Lulu, Gu, Lianfeng, Sun, Jing, Kong, Xiangfeng, Liu, Chunyan, Cao, Xiaofeng
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.05.2016
• Subjects: Arabidopsis; Arabidopsis - genetics; Arabidopsis Proteins - genetics; Biological Sciences; Eukaryotes; Flowers & plants; Genes; Genotype & phenotype; Methylation; Mutants; Mutation; Protein-Arginine N-Methyltransferases - genetics; Proteins; RNA Precursors - genetics; RNA Splicing - genetics; Saccharomyces cerevisiae Proteins - genetics; Spliceosomes - genetics; arginine methylation; AtPRMT5; Prp19C/NTC; pre-mRNA splicing; protein arginine methyltransferase

Protein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is involved in amultitude of biological processes in eukaryotes. Symmetric arginine dimethylation mediated by PRMT5 modulates constitutive and alternative pre-mRNA splicing of diverse genes to regulate normal gro...