Integrating Evolutionary and Functional Tests of Adaptive Hypotheses: A Case Study of Altitudinal Differentiation in Hemoglobin Function in an Andean Sparrow, Zonotrichia capensis - Cheviron, Zachary A.; Natarajan, Chandrasekhar; Projecto-Garcia, Joana; Eddy, Douglas K.; Jones, Jennifer; Carling, Matthew D.; Witt, Christopher C.; Moriyama, Hideaki; Weber, Roy E.; Fago, Angela; Storz, Jay F. (Molecular biology and evolution, 2014)
Keywords: Adaptation, Physiological; Alleles; alpha-Globins - genetics; alpha-Globins - metabolism; Altitude; Amino acids; Animals; Biological Transport; Birds; Differentiation; Discoveries; Functional testing; Gene Expression; Gene Frequency; Gene polymorphism; Genes; Genetic diversity; Genomic analysis; Genotype & phenotype; Genotypes; Hemoglobin; Hemoglobins - genetics; Hemoglobins - metabolism; Hypoxia - genetics; Hypoxia - metabolism; Isoforms; Mutants; Mutation; Oxygen - metabolism; Oxygenation; Partial pressure; Polymorphism; Protein Engineering; Protein Isoforms - genetics; Protein Isoforms - metabolism; Protein Subunits - genetics; Protein Subunits - metabolism; Proteins; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Site-directed mutagenesis; Sparrows - physiology; Vertebrates; Zonotrichia capensis; functional synthesis; hypoxia; adaptation; high-altitude adaptation; protein evolution