Mitochondria-engine with self-regulation to restore degenerated intervertebral disc cells via bioenergetic robust hydrogel design

• Published in: Bioactive materials Vol. 40; pp. 1 - 18
• Main Authors: Wang, Juehan, Jiang, Yulin, Zhu, Ce, Liu, Zheng, Qi, Lin, Ding, Hong, Wang, Jing, Huang, Yong, Li, Yubao, Song, Yueming, Feng, Ganjun, Zhang, Li, Liu, Limin
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.10.2024; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Intervertebral disc degeneration; l-arginine; Mitochondrial dysfunction; Polyurethan scaffold; ROS scavenging; Intervertebral disc degeneration; Mitochondrial dysfunction; Polyurethan scaffold; l-arginine; ROS scavenging

Previous studies have confirmed that intervertebral disc degeneration (IDD) is closely associated with inflammation-induced reactive oxygen species (ROS) and resultant cell mitochondrial membrane potential (MMP) decline. Clearance of ROS in an inflammatory environment is essential for breaking the v...