Sustained-release of FGF-2 from a hybrid hydrogel of heparin-poloxamer and decellular matrix promotes the neuroprotective effects of proteins after spinal injury

• Published in: International journal of nanomedicine Vol. 13; pp. 681 - 694
• Main Authors: Xu, He-Lin, Tian, Fu-Rong, Xiao, Jian, Chen, Pian-Pian, Xu, Jie, Fan, Zi-Liang, Yang, Jing-Jing, Lu, Cui-Tao, Zhao, Ying-Zheng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Adsorption; Animals; Anticoagulants; Apoptosis; Apoptosis - drug effects; Axons - drug effects; basic fibroblast growth factor; Biomedical materials; decellularized extracellular matrix; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacology; Endoplasmic reticulum; Extracellular matrix; Extracellular Matrix - chemistry; Female; Fibroblast Growth Factor 2 - pharmacokinetics; Fibroblast Growth Factor 2 - pharmacology; Fibroblast growth factors; Fibroblasts; Growth factors; Heparin - chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacokinetics; Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology; Hydrogels; Neurons; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacokinetics; Neuroprotective Agents - pharmacology; Novels; Original Research; PC12 Cells; Phase transitions; Poloxamer - chemistry; Polymers; Proteins; Rats; Rats, Sprague-Dawley; Signal transduction; Spinal Cord - cytology; Spinal cord injuries; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - pathology; spinal cord injury; Stem cells; Studies; Temperature; thermosensitive hydrogel; United States > US; China; decellularized extracellular matrix; spinal cord injury; adsorption; thermosensitive hydrogel; basic fibroblast growth factor

The short lifetime of protein-based therapies has largely limited their therapeutic efficacy in injured nervous post-spinal cord injury (post-SCI). In this study, an affinity-based hydrogel delivery system provided sustained-release of proteins, thereby extending the efficacy of such therapies. The...