Arteriolar Function in Visceral Adipose Tissue Is Impaired in Human Obesity

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 32; no. 2; pp. 467 - 473
• Main Authors: Farb, Melissa G., Ganley-Leal, Lisa, Mott, Melanie, Liang, YanMei, Ercan, Bahadir, Widlansky, Michael E., Bigornia, Sherman J., Fiscale, Antonino J., Apovian, Caroline M., Carmine, Brian, Hess, Donald T., Vita, Joseph A., Gokce, Noyan
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.02.2012; Lippincott Williams & Wilkins
• Subjects: Adult; Arterioles - drug effects; Arterioles - physiopathology; Atherosclerosis (general aspects, experimental research); Bariatric Surgery; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Humans; Intra-Abdominal Fat - blood supply; Intra-Abdominal Fat - physiopathology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nitroprusside - pharmacology; Obesity - physiopathology; Obesity - surgery; Papaverine - pharmacology; Subcutaneous Fat - blood supply; Subcutaneous Fat - physiopathology; Vasodilator Agents - pharmacology; Vasomotor System - drug effects; Vasomotor System - physiopathology; Human; Obesity; adiposity; Adipose tissue; Nutrition disorder; arteries; Cardiovascular disease; Inflammation; Vasodilation; Endothelium; Vascular disease; Vasomotricity; Atherosclerosis; Nutritional status

OBJECTIVE—The purpose of this study was to characterize the relationship between adipose tissue phenotype and depot-specific microvascular function in fat. METHODS AND RESULTS—In 30 obese subjects (age 42±11 years, body mass index 46±11 kg/m) undergoing bariatric surgery, we intraoperatively collect...