Pharmacokinetic and pharmacodynamic variability of fluindione in octogenarians

• Published in: Clinical pharmacology and therapeutics Vol. 91; no. 5; p. 777
• Main Authors: Comets, E, Diquet, B, Legrain, S, Huisse, M-G, Godon, A, Bruhat, C, Chauveheid, M-P, Delpierre, S, Duval, X, Berrut, G, Verstuyft, C, Aumont, M-C, Mentré, F
• Format: Journal Article
• Language: English
• Published: United States 01.05.2012
• Subjects: Aged; Aged, 80 and over; Anticoagulants - pharmacokinetics; Anticoagulants - pharmacology; Female; Humans; International Normalized Ratio; Male; Phenindione - analogs & derivatives; Phenindione - pharmacokinetics; Phenindione - pharmacology

In the PREPA observational study, we investigated the factors influencing pharmacokinetic and pharmacodynamic variability in the responses to fluindione, an oral anticoagulant drug, in a general population of octogenarian inpatients.Measurements of fluindione concentrations and international normali...