Regulated Apoptosis of Genetically Modified Hematopoietic Stem and Progenitor Cells Via an Inducible Caspase‐9 Suicide Gene in Rhesus Macaques - Barese, Cecilia N.; Felizardo, Tania C.; Sellers, Stephanie E.; Keyvanfar, Keyvan; Di Stasi, Antonio; Metzger, Mark E.; Krouse, Allen E.; Donahue, Robert E.; Spencer, David M.; Dunbar, Cynthia E. (Stem cells (Dayton, Ohio), 2015)
Keywords: Animals; Apoptosis - physiology; Caspase 9 - biosynthesis; Caspase 9 - genetics; Gene therapy; Genes; Genes, Transgenic, Suicide; Genetic Therapy; Genetic Vectors; Genotoxicity; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - enzymology; HSC transplantation; iCasp9; Macaca mulatta; Medical research; Primates; Risk reduction; Safety; Stem cells; Suicide; Suicide gene; HSC transplantation; Gene therapy; Suicide gene; Genotoxicity; iCasp9