Cardiac cachexia: hic et nunc

Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenged, more precisely, the addition of new criteria on top of obligatory weight loss. The pathophysiolog...

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Published inJournal of cachexia, sarcopenia and muscle Vol. 7; no. 3; pp. 246 - 260
Main Authors Loncar, Goran, Springer, Jochen, Anker, Markus, Doehner, Wolfram, Lainscak, Mitja
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.06.2016
John Wiley and Sons Inc
Subjects
Biomarkers
Cachexia
Chronic illnesses
Cytokines
Diagnosis
Disease
Growth factors
Health care
Heart failure
Insulin resistance
Metabolism
Musculoskeletal system
Oxidative stress
Prevalence
Proteins
Review
Reviews
Sarcopenia
Studies
Treatment
Tumor necrosis factor-TNF
Heart failure
Cachexia
Prevalence
Treatment
Diagnosis
Online AccessGet full text
ISSN2190-5991
2190-6009
DOI10.1002/jcsm.12118

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Abstract Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenged, more precisely, the addition of new criteria on top of obligatory weight loss. The pathophysiology of CC is complex and multifactorial. A better understanding of pathophysiological pathways in body wasting will contribute to establish potentially novel treatment strategies. The complex biochemical network related with CC and HF pathophysiology underlines that a single biomarker cannot reflect all of the features of the disease. Biomarkers that could pick up the changes in body composition before they convey into clinical manifestations of CC would be of great importance. The development of preventive and therapeutic strategies against cachexia, sarcopenia, and wasting disorders is perceived as an urgent need by healthcare professionals. The treatment of body wasting remains an unresolved challenge to this day. As CC is a multifactorial disorder, it is unlikely that any single agent will be completely effective in treating this condition. Among all investigated therapeutic strategies, aerobic exercise training in HF patients is the most proved to counteract skeletal muscle wasting and is recommended by treatment guidelines for HF.
AbstractList Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenged, more precisely, the addition of new criteria on top of obligatory weight loss. The pathophysiology of CC is complex and multifactorial. A better understanding of pathophysiological pathways in body wasting will contribute to establish potentially novel treatment strategies. The complex biochemical network related with CC and HF pathophysiology underlines that a single biomarker cannot reflect all of the features of the disease. Biomarkers that could pick up the changes in body composition before they convey into clinical manifestations of CC would be of great importance. The development of preventive and therapeutic strategies against cachexia, sarcopenia, and wasting disorders is perceived as an urgent need by healthcare professionals. The treatment of body wasting remains an unresolved challenge to this day. As CC is a multifactorial disorder, it is unlikely that any single agent will be completely effective in treating this condition. Among all investigated therapeutic strategies, aerobic exercise training in HF patients is the most proved to counteract skeletal muscle wasting and is recommended by treatment guidelines for HF.
Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenged, more precisely, the addition of new criteria on top of obligatory weight loss. The pathophysiology of CC is complex and multifactorial. A better understanding of pathophysiological pathways in body wasting will contribute to establish potentially novel treatment strategies. The complex biochemical network related with CC and HF pathophysiology underlines that a single biomarker cannot reflect all of the features of the disease. Biomarkers that could pick up the changes in body composition before they convey into clinical manifestations of CC would be of great importance. The development of preventive and therapeutic strategies against cachexia, sarcopenia, and wasting disorders is perceived as an urgent need by healthcare professionals. The treatment of body wasting remains an unresolved challenge to this day. As CC is a multifactorial disorder, it is unlikely that any single agent will be completely effective in treating this condition. Among all investigated therapeutic strategies, aerobic exercise training in HF patients is the most proved to counteract skeletal muscle wasting and is recommended by treatment guidelines for HF.Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenged, more precisely, the addition of new criteria on top of obligatory weight loss. The pathophysiology of CC is complex and multifactorial. A better understanding of pathophysiological pathways in body wasting will contribute to establish potentially novel treatment strategies. The complex biochemical network related with CC and HF pathophysiology underlines that a single biomarker cannot reflect all of the features of the disease. Biomarkers that could pick up the changes in body composition before they convey into clinical manifestations of CC would be of great importance. The development of preventive and therapeutic strategies against cachexia, sarcopenia, and wasting disorders is perceived as an urgent need by healthcare professionals. The treatment of body wasting remains an unresolved challenge to this day. As CC is a multifactorial disorder, it is unlikely that any single agent will be completely effective in treating this condition. Among all investigated therapeutic strategies, aerobic exercise training in HF patients is the most proved to counteract skeletal muscle wasting and is recommended by treatment guidelines for HF.
Author Doehner, Wolfram
Springer, Jochen
Anker, Markus
Loncar, Goran
Lainscak, Mitja
AuthorAffiliation 5 Center for Stroke Research Berlin Charité Universitätsmedizin Berlin Germany
6 Department of Cardiology and Department of Research and Education General Hospital Celje Celje Slovenia
3 Innovative Clinical Trials, Department of Cardiology and Pneumology University Medical Center Göttingen (UMG) Göttingen Germany
2 School of Medicine University of Belgrade Belgrade Serbia
7 Faculty of Medicine University of Ljubljana Ljubljana Slovenia
1 Department of Cardiology Clinical Hospital Zvezdara Belgrade Serbia
4 Department of Cardiology Charité – Universitätsmedizin Berlin Germany
AuthorAffiliation_xml – name: 2 School of Medicine University of Belgrade Belgrade Serbia
– name: 3 Innovative Clinical Trials, Department of Cardiology and Pneumology University Medical Center Göttingen (UMG) Göttingen Germany
– name: 6 Department of Cardiology and Department of Research and Education General Hospital Celje Celje Slovenia
– name: 1 Department of Cardiology Clinical Hospital Zvezdara Belgrade Serbia
– name: 7 Faculty of Medicine University of Ljubljana Ljubljana Slovenia
– name: 4 Department of Cardiology Charité – Universitätsmedizin Berlin Germany
– name: 5 Center for Stroke Research Berlin Charité Universitätsmedizin Berlin Germany
Author_xml – sequence: 1
  givenname: Goran
  surname: Loncar
  fullname: Loncar, Goran
  organization: University of Belgrade
– sequence: 2
  givenname: Jochen
  surname: Springer
  fullname: Springer, Jochen
  organization: University Medical Center Göttingen (UMG)
– sequence: 3
  givenname: Markus
  surname: Anker
  fullname: Anker, Markus
  organization: Charité – Universitätsmedizin
– sequence: 4
  givenname: Wolfram
  surname: Doehner
  fullname: Doehner, Wolfram
  organization: Charité Universitätsmedizin
– sequence: 5
  givenname: Mitja
  surname: Lainscak
  fullname: Lainscak, Mitja
  organization: University of Ljubljana
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27386168$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2016 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders
2016. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2016 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders
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Issue 3
Keywords Heart failure
Cachexia
Prevalence
Treatment
Diagnosis
Language English
License Attribution-NonCommercial-NoDerivs
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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PublicationTitle Journal of cachexia, sarcopenia and muscle
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Snippet Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent...
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StartPage 246
SubjectTerms Biomarkers
Cachexia
Chronic illnesses
Cytokines
Diagnosis
Disease
Growth factors
Health care
Heart failure
Insulin resistance
Metabolism
Musculoskeletal system
Oxidative stress
Prevalence
Proteins
Review
Reviews
Sarcopenia
Studies
Treatment
Tumor necrosis factor-TNF
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Title Cardiac cachexia: hic et nunc
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcsm.12118
https://www.ncbi.nlm.nih.gov/pubmed/27386168
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Volume 7
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