Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

• Published in: Circulation research Vol. 128; no. 4; pp. e46 - e62
• Main Authors: Mäe, Maarja A., He, Liqun, Nordling, Sofia, Vazquez-Liebanas, Elisa, Nahar, Khayrun, Jung, Bongnam, Li, Xidan, Tan, Bryan C., Chin Foo, Juat, Cazenave-Gassiot, Amaury, Wenk, Markus R., Zarb, Yvette, Lavina, Barbara, Quaggin, Susan E., Jeansson, Marie, Gu, Chengua, Silver, David L., Vanlandewijck, Michael, Butcher, Eugene C., Keller, Annika, Betsholtz, Christer
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 19.02.2021
• Subjects: angiopoietin 2; Animals; blood-brain barrier; Blood-Brain Barrier - cytology; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - pathology; Cell Proliferation; Cells, Cultured; endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - physiology; Lymphokines - deficiency; Lymphokines - genetics; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; pericyte; Pericytes - cytology; Pericytes - metabolism; Pericytes - pathology; permeability; Platelet-Derived Growth Factor - deficiency; Platelet-Derived Growth Factor - genetics; Single-Cell Analysis; Transcriptome; blood-brain barrier; endothelial cells; angiopoietin 2; pericyte; permeability

Pericytes are capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair. Loss of pericytes has been described in several brain disorders, and genetically induced pericyte deficiency in the brain leads to increased macromolecular leakage acros...