A Critical Evaluation of Influence of Ethanol and Diet on Salsolinol Enantiomers in Humans and Rats

• Published in: Alcoholism, clinical and experimental research Vol. 34; no. 2; pp. 242 - 250
• Main Authors: Lee, Jeongrim, Ramchandani, Vijay A., Hamazaki, Kei, Engleman, Eric A., McBride, William J., Li, Ting-Kai, Kim, Hee-Yong
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2010; Wiley
• Subjects: Adult; Alcohol Drinking - genetics; Alcohol Drinking - psychology; Alcohol-Non-Preferring Rats; Alcohol-Preferring Rats; Alcoholism and acute alcohol poisoning; Animals; Biogenic Amines - analysis; Biological and medical sciences; Central Nervous System Depressants - pharmacology; Chromatography, High Pressure Liquid; Diet; Dopamine; Dopamine - blood; Ethanol; Ethanol - pharmacology; Food Analysis; HPLC/MS/MS; Humans; Isoquinolines - blood; Isoquinolines - chemistry; Male; Medical sciences; Middle Aged; Musa; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Salsolinol; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Striatum; Tandem Mass Spectrometry; Toxicology; Young Adult; Rat; Central nervous system; HPLC chromatography; Encephalon; Isomer; Alcoholic beverage; Striatum; Enantiomer; Human; Evaluation; Salsolinol; Dopamine; HPLC/MS/MS; Ethanol; Nutrition; Rodentia; Alcohol-Preferring Rats; Basal ganglion; Corpus striatum; Catecholamine; Feeding; Nucleus accumbens; Vertebrata; Mammalia; Diet; Animal; Neurotransmitter; Alcohol-Non-Preferring Rats

Background:  (R/S)‐Salsolinol (SAL), a condensation product of dopamine (DA) with acetaldehyde, has been speculated to have a role in the etiology of alcoholism. Earlier studies have shown the presence of SAL in biological fluids and postmortem brains from both alcoholics and nonalcoholics. However,...