Liver is the major source of elevated serum lipocalin‐2 levels after bacterial infection or partial hepatectomy: A critical role for IL‐6/STAT3

• Published in: Hepatology (Baltimore, Md.) Vol. 61; no. 2; pp. 692 - 702
• Main Authors: Xu, Ming‐Jiang, Feng, Dechun, Wu, Hailong, Wang, Hua, Chan, Yvonne, Kolls, Jay, Borregaard, Niels, Porse, Bo, Berger, Thorsten, Mak, Tak W., Cowland, Jack B., Kong, Xiaoni, Gao, Bin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.02.2015
• Subjects: Acute-Phase Proteins; Animals; Bacterial infections; Bacterial Infections - blood; Escherichia coli; Hepatectomy; Hepatocytes - metabolism; Hepatology; Infections; Interleukin-6 - metabolism; Klebsiella pneumoniae; Lipocalin-2; Lipocalins - blood; Liver Regeneration; Mice, Inbred C57BL; Oncogene Proteins - blood; Receptors, Interleukin-6 - metabolism; Rodents; STAT3 Transcription Factor - metabolism

Lipocalin‐2 (LCN2) was originally isolated from human neutrophils and termed neutrophil gelatinase‐associated lipocalin (NGAL). However, the functions of LCN2 and the cell types that are primarily responsible for LCN2 production remain unclear. To address these issues, hepatocyte‐specific Lcn2 knock...