Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading‐dependent changes linked to muscle atrophy

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 14; no. 1; pp. 439 - 451
• Main Authors: Murgia, Marta, Brocca, Lorenza, Monti, Elena, Franchi, Martino V., Zwiebel, Maximilian, Steigerwald, Sophia, Giacomello, Emiliana, Sartori, Roberta, Zampieri, Sandra, Capovilla, Giovanni, Gasparini, Mladen, Biolo, Gianni, Sandri, Marco, Mann, Matthias, Narici, Marco V.
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.02.2023; John Wiley and Sons Inc; Wiley
• Subjects: Atrophy; Bed rest; Bed Rest - adverse effects; Biomarkers; Cachexia; Cancer; Chromatography; Healthy Volunteers; Humans; Male; Mass spectrometry; Muscular Atrophy - etiology; Musculoskeletal system; Older people; Original; Patients; Peptides; Plasma; Proteins; Proteome; Proteomics; Sarcopenia; Scientific imaging; Skeletal muscle; Atrophy; Plasma; Cachexia; Bed rest; Skeletal muscle; Proteomics

Background Inactivity and unloading induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the musculoskeletal system. It not only provides information for bed‐ridden patients care, but it is also a ground‐based sp...