IgE‐based immunotherapy of cancer: challenges and chances

• Published in: Allergy (Copenhagen) Vol. 69; no. 2; pp. 137 - 149
• Main Authors: Singer, J., Jensen‐Jarolim, E.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.02.2014
• Subjects: AllergoOncology; Animals; Antibodies, Monoclonal - therapeutic use; Cancer; comparative oncology; Humans; IgE; Immunoglobulin E - therapeutic use; Immunoglobulins; Immunotherapy; Immunotherapy - methods; Neoplasms - therapy; passive immunotherapy; Review; AllergoOncology; passive immunotherapy; IgE; comparative oncology

Passive immunotherapy with monoclonal antibodies is an indispensable cornerstone of clinical oncology. Notably, all FDA‐approved antibodies comprise the IgG class, although numerous research articles proposed monoclonal antibodies of the IgM, IgG, IgA and IgE classes directed specifically against tu...