Changes in Insulin Secretion and Insulin Sensitivity in Relation to the Glycemic Outcomes in Subjects With Impaired Glucose Tolerance in the Indian Diabetes Prevention Programme-1 (IDPP-1)
OBJECTIVE: The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those fo...
Saved in:
| Published in | Diabetes care Vol. 32; no. 10; pp. 1796 - 1801 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Alexandria, VA
American Diabetes Association
01.10.2009
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | OBJECTIVE: The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied. RESEARCH DESIGN AND METHODS: For this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and β-cell function (insulinogenic index [ΔI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome. RESULTS: Subjects with IGT showed a deterioration in β-cell function with time. Individuals with higher insulin resistance and/or low β-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, χ² = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal ΔI/G (51.2%, χ² = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal β-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes. CONCLUSIONS: In the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies. |
|---|---|
| AbstractList | The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied.
For this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and beta-cell function (insulinogenic index [DeltaI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome.
Subjects with IGT showed a deterioration in beta-cell function with time. Individuals with higher insulin resistance and/or low beta-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, chi(2) = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal DeltaI/G (51.2%, chi(2) = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal beta-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes.
In the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies. The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied. For this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and β-cell function (insulinogenic index [ΔI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome. Subjects with IGT showed a deterioration in β-cell function with time. Individuals with higher insulin resistance and/or low β-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, χ^sup 2^ = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal ΔI/G (51.2%, χ^sup 2^ = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal β-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes. In the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies. OBJECTIVE: The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied. RESEARCH DESIGN AND METHODS: For this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and β-cell function (insulinogenic index [ΔI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome. RESULTS: Subjects with IGT showed a deterioration in β-cell function with time. Individuals with higher insulin resistance and/or low β-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, χ² = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal ΔI/G (51.2%, χ² = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal β-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes. CONCLUSIONS: In the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies. Changes in Insulin Secretion and Insulin Sensitivity in Relation to the Glycemic Outcomes in Subjects With Impaired Glucose Tolerance in the Indian Diabetes Prevention Programme-1 (IDPP-1) Chamukuttan Snehalatha , DSC , Simon Mary , BSC , Sundaram Selvam , MPHIL , Cholaiyil Kizhakathil Sathish Kumar , BSC , Samith Babu Ananth Shetty , MBBS, MDRC , Arun Nanditha , MD and Ambady Ramachandran , MD From the India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India. Corresponding author: Ambady Ramachandran, ramachandran{at}vsnl.com . Abstract OBJECTIVE The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years ( n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied. RESEARCH DESIGN AND METHODS For this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and β-cell function (insulinogenic index [ΔI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome. RESULTS Subjects with IGT showed a deterioration in β-cell function with time. Individuals with higher insulin resistance and/or low β-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, χ 2 = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal ΔI/G (51.2%, χ 2 = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal β-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes. CONCLUSIONS In the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies. Footnotes The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Received April 8, 2009. Accepted June 18, 2009. © 2009 by the American Diabetes Association. The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied.OBJECTIVEThe Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied.For this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and beta-cell function (insulinogenic index [DeltaI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome.RESEARCH DESIGN AND METHODSFor this analysis, 437 subjects (93 subjects with normoglycemia [NGT], 150 subjects with IGT, and 194 subjects with diabetes) were included. Measurements of anthropometry, plasma glucose, and plasma insulin at baseline and at follow-up were available for all of them. Indexes of insulin resistance (homeostasis model assessment of insulin resistance) and beta-cell function (insulinogenic index [DeltaI/G]: 30-min fasting insulin divided by 30-min glucose) were also analyzed in relation to the outcome.Subjects with IGT showed a deterioration in beta-cell function with time. Individuals with higher insulin resistance and/or low beta-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, chi(2) = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal DeltaI/G (51.2%, chi(2) = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal beta-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes.RESULTSSubjects with IGT showed a deterioration in beta-cell function with time. Individuals with higher insulin resistance and/or low beta-cell function at baseline had poor outcome on follow-up. In relation to no abnormalities, the highest incidence of diabetes occurred when both abnormalities coexisted (54.9 vs. 33.7%, chi(2) = 7.53, P = 0.006). Individuals having abnormal insulin resistance (41.1%) or abnormal DeltaI/G (51.2%, chi(2) = 4.87, P = 0.027 vs. no abnormalities) had lower incidence. Normal beta-cell function with improved insulin sensitivity facilitated reversal to NGT, whereas deterioration in both resulted in diabetes. The beneficial changes were better with intervention than in the control group. Intervention groups had higher rates of NGT and lower rates of diabetes.In the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies.CONCLUSIONSIn the IDPP-1 subjects, beneficial outcomes occurred because of improved insulin action and sensitivity caused by the intervention strategies. |
| Audience | Professional |
| Author | Mary, Simon Shetty, Samith Babu Ananth Nanditha, Arun Sathish Kumar, Cholaiyil Kizhakathil Ramachandran, Ambady Selvam, Sundaram Snehalatha, Chamukuttan |
| Author_xml | – sequence: 1 fullname: Snehalatha, Chamukuttan – sequence: 2 fullname: Mary, Simon – sequence: 3 fullname: Selvam, Sundaram – sequence: 4 fullname: Sathish Kumar, Cholaiyil Kizhakathil – sequence: 5 fullname: Shetty, Samith Babu Ananth – sequence: 6 fullname: Nanditha, Arun – sequence: 7 fullname: Ramachandran, Ambady |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21997766$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19587369$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9k9tu1DAQhiNURA9wwQtABOJQobRO7MTxDVLVQlmpUle0FZeWY0-yrhK72ElR342Hw-4upa1WyBe2xt_8Ho3_2U42jDWQJC9ztFdgTPeVRCxDFa2eJFs5w2VWlqTeSLZQTlhWMlZsJtveXyKECKnrZ8lmzsqa4optJb8PF8J04FNt0pnxUx_2M5AORm1NKoy6FzVej_pajzcR_g69uGVGm44LSI_7GwmDlunpNEo7LBXPpuYS5OjTH3pcpLPhSmgHKrCTtB7Sc9uDE0ZCZKPIzCgtTHqkRQNjkJg7uAZz-8zc2c6JYYAsTz_OjubzLN99njxtRe_hxWrfSS6-fjk__JadnB7PDg9OMlmSospEi1rFGoSFaiXOCVW1AEYAwm1DhaKNqttWVKRVIOoG5UWFCGqwkq0kRU3wTvJ5qXs1NQMoGUpyoudXTg_C3XArNH94Y_SCd_aaF7QsGKJB4MNKwNmfE_iRD9pL6HthwE6eU4zDN9GSBfL9f0lSEVQxVAfwzSPw0k7OhDbwosAIU0oj9HYJdaIHrk1rQ3kyKvKDIke4qgsWq8vWUB2Y8Dl9cFqrQ_gBv7eGD0tFA6xNeHW_f3eN-2vDALxbAcJL0bfRFNrfcUUemkOrKnC7S046672D9p8U4nEUeBwFHkchsPuPWKnHW8uGanW_NuPTMmOhu8Wv4FSuVkaMBylCABcxL6cs0q-XdCssF50L9V6cFSjHKK_qihCG_wCr8iOg |
| CODEN | DICAD2 |
| CitedBy_id | crossref_primary_10_1136_bmj_n1449 crossref_primary_10_1016_j_diabres_2024_111637 crossref_primary_10_1186_s12944_024_02060_w crossref_primary_10_1186_1472_6882_13_104 crossref_primary_10_7326_M15_0452 crossref_primary_10_1016_j_mcna_2010_11_006 crossref_primary_10_1001_jamanetworkopen_2023_4989 crossref_primary_10_2337_dc11_0925 crossref_primary_10_1111_j_1464_5491_2011_03392_x crossref_primary_10_2217_dmt_13_24 crossref_primary_10_1007_s40265_015_0416_8 crossref_primary_10_1038_s43856_024_00466_2 crossref_primary_10_4158_EP11226_OR crossref_primary_10_1016_S0140_6736_12_60828_9 crossref_primary_10_1016_j_diabres_2011_07_008 crossref_primary_10_1111_jdi_12352 crossref_primary_10_1142_S0192415X1350002X crossref_primary_10_1186_1475_2840_13_93 crossref_primary_10_1007_s00592_015_0718_z crossref_primary_10_1210_js_2016_1116 crossref_primary_10_1016_S2213_8587_23_00235_8 crossref_primary_10_1002_14651858_CD008558_pub2 crossref_primary_10_1016_j_clnu_2019_02_027 crossref_primary_10_37648_ijrmst_v15i01_006 crossref_primary_10_1007_s11886_014_0476_5 crossref_primary_10_1186_s12967_023_04402_1 crossref_primary_10_4158_EP10112_RA crossref_primary_10_1016_j_pcd_2021_12_009 crossref_primary_10_1111_joim_13214 crossref_primary_10_1002_dmrr_1019 crossref_primary_10_1007_s00125_017_4407_z crossref_primary_10_2337_dc09_1150 crossref_primary_10_1111_dme_13921 crossref_primary_10_1111_j_1464_5491_2012_03753_x crossref_primary_10_1111_dme_13865 crossref_primary_10_2478_jtim_2020_0020 crossref_primary_10_1007_s00125_019_4905_2 crossref_primary_10_1016_j_diabres_2018_05_042 crossref_primary_10_1073_pnas_1417197112 crossref_primary_10_3389_fendo_2024_1388751 crossref_primary_10_2337_dc11_1272 crossref_primary_10_1007_s40119_016_0057_3 crossref_primary_10_1016_j_diabres_2023_110839 crossref_primary_10_2337_dc14_0407 crossref_primary_10_1002_biof_1209 crossref_primary_10_1007_s00125_014_3439_x crossref_primary_10_1002_14651858_CD003054_pub4 crossref_primary_10_1016_S0140_6736_12_60283_9 |
| Cites_doi | 10.1111/j.1464-5491.1995.tb00399.x 10.2337/diabetes.51.9.2796 10.1016/0026-0495(95)90003-9 10.1007/BF00280883 10.1007/s00125-005-0097-z 10.1016/S0140-6736(08)60766-7 10.1056/NEJM198812083192302 10.1016/S0140-6736(06)69420-8 10.1002/pdi.1960160112 10.2337/diabetes.52.10.2532 10.1079/NRR19930010 10.1016/S0168-8227(03)00060-3 10.2337/diabetes.54.8.2404 10.2337/diabetes.55.04.06.db05-1100 10.1046/j.1464-5491.2002.00835.x 10.1007/s00125-005-0004-7 10.1172/JCI7231 10.1046/j.1464-5491.1999.00084.x 10.2337/diacare.20.4.537 10.2337/diab.44.11.1249 10.1056/NEJMoa012512 10.1056/NEJM200105033441801 |
| ContentType | Journal Article |
| Copyright | 2009 INIST-CNRS COPYRIGHT 2009 American Diabetes Association Copyright American Diabetes Association Oct 2009 2009 by the American Diabetes Association. 2009 |
| Copyright_xml | – notice: 2009 INIST-CNRS – notice: COPYRIGHT 2009 American Diabetes Association – notice: Copyright American Diabetes Association Oct 2009 – notice: 2009 by the American Diabetes Association. 2009 |
| DBID | FBQ AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7RV 7X2 7X7 7XB 88E 88I 8AF 8AO 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AN0 ATCPS AZQEC BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K9- K9. KB0 M0K M0R M0S M0T M1P M2O M2P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U S0X 7S9 L.6 7X8 5PM |
| DOI | 10.2337/dc09-0676 |
| DatabaseName | AGRIS CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest British Nursing Database Agricultural & Environmental Science Collection ProQuest Central Essentials eLibrary ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea ProQuest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library SciTech Premium Collection Consumer Health Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Agricultural Science Database Consumer Health Database ProQuest Health & Medical Collection Healthcare Administration Database Medical Database Research Library Science Database Research Library (Corporate) ProQuest Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic SIRS Editorial AGRICOLA AGRICOLA - Academic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Research Library Prep ProQuest Central Student ProQuest Central Essentials elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Health Research Premium Collection Natural Science Collection Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Family Health ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest One Academic Middle East (New) SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Central Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Agricultural & Environmental Science Collection ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest Science Journals British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central Database Suite (ProQuest) url: https://www.proquest.com/central sourceTypes: Aggregation Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1935-5548 |
| EndPage | 1801 |
| ExternalDocumentID | PMC2752907 1883661951 A210368297 19587369 21997766 10_2337_dc09_0676 diacare_32_10_1796 US201301686449 |
| Genre | Randomized Controlled Trial Journal Article |
| GeographicLocations | Asia India |
| GroupedDBID | --- -ET ..I .55 .GJ .XZ 08P 0R~ 18M 29F 2WC 3O- 4.4 41~ 53G 5GY 5RE 5RS 5VS 6PF 7RV 7X2 7X7 88E 88I 8AF 8AO 8C1 8F7 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAIKC AAKAS AAMNW AAQOH AAQQT AAWTL AAYEP AAYJJ ABOCM ABPPZ ABUWG ACGFO ACGOD ADBBV ADZCM AEGXH AENEX AERZD AFFNX AFKRA AFOSN AFRAH AHMBA AI. AIAGR ALIPV ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI ATCPS AZQEC BAWUL BCR BCU BEC BENPR BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BTFSW BVXVI C1A CCPQU CS3 DIK DU5 DWQXO E3Z EBS EDB EJD EMOBN EX3 F5P FBQ FYUFA GNUQQ GUQSH GX1 H13 HCIFZ HMCUK HZ~ IAG IAO IEA IHR INH INR IOF IPO ITC J5H K9- KQ8 L7B M0K M0R M0T M1P M2O M2P M2Q M5~ N4W NAPCQ O5R O5S O9- OK1 OVD P2P PCD PEA PHGZT PQQKQ PROAC PSQYO Q2X RHI S0X SJFOW SV3 TDI TEORI TR2 TWZ UKHRP VH1 VVN W8F WH7 WHG WOQ WOW X7M YHG YOC ZCG ZGI ZXP ~KM - 0R 1AW 3V. AASXA ABFLS ABPTK ACJLH ACVYA ADACO BBAFP ET GJ HZ IGG KM M5 MBDVC O0- PADUT PQEST PQUKI PRINS RHF XZ ZA5 AAFWJ AAYXX CITATION PHGZM IQODW CGR CUY CVF ECM EIF NPM PJZUB PPXIY PMFND 7XB 8FK K9. PKEHL Q9U 7S9 L.6 PUEGO 7X8 5PM |
| ID | FETCH-LOGICAL-c5426-af0fd9b03adfc3147d8ae94ee542b7ad7bd8ffa64fdea8b0126040b3dcfc42843 |
| IEDL.DBID | 7X7 |
| ISSN | 0149-5992 1935-5548 |
| IngestDate | Thu Aug 21 17:34:04 EDT 2025 Fri Jul 11 10:38:30 EDT 2025 Sun Aug 24 04:15:28 EDT 2025 Sat Jul 26 02:29:27 EDT 2025 Tue Jun 17 21:57:40 EDT 2025 Thu Jun 12 23:57:55 EDT 2025 Tue Jun 10 20:58:36 EDT 2025 Mon Jul 21 05:56:51 EDT 2025 Thu Apr 10 09:00:43 EDT 2025 Thu Apr 24 22:57:12 EDT 2025 Tue Jul 01 04:20:20 EDT 2025 Fri Jan 15 19:48:07 EST 2021 Thu Apr 03 09:44:30 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Endocrinopathy Human Sanitary program Pancreatic hormone Prognosis Nutrition Secretion Insulin sensitivity Diabetes mellitus Metabolic diseases Change Insulin Prevention Evolution Indian Impaired glucose tolerance Endocrinology Glycemia |
| Language | English |
| License | CC BY 4.0 Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5426-af0fd9b03adfc3147d8ae94ee542b7ad7bd8ffa64fdea8b0126040b3dcfc42843 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC2752907 |
| PMID | 19587369 |
| PQID | 223037778 |
| PQPubID | 47715 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2752907 crossref_citationtrail_10_2337_dc09_0676 fao_agris_US201301686449 proquest_journals_223037778 pascalfrancis_primary_21997766 gale_infotracmisc_A210368297 proquest_miscellaneous_46406908 gale_infotracacademiconefile_A210368297 crossref_primary_10_2337_dc09_0676 proquest_miscellaneous_733599759 pubmed_primary_19587369 highwire_diabetes_diacare_32_10_1796 gale_infotracgeneralonefile_A210368297 |
| ProviderPackageCode | RHF RHI CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-10-00 |
| PublicationDateYYYYMMDD | 2009-10-01 |
| PublicationDate_xml | – month: 10 year: 2009 text: 2009-10-00 |
| PublicationDecade | 2000 |
| PublicationPlace | Alexandria, VA |
| PublicationPlace_xml | – name: Alexandria, VA – name: United States – name: Alexandria |
| PublicationTitle | Diabetes care |
| PublicationTitleAlternate | Diabetes Care |
| PublicationYear | 2009 |
| Publisher | American Diabetes Association |
| Publisher_xml | – name: American Diabetes Association |
| References | Tumilehto (2022031218143404900_B1) 2001; 344 Ramachandran (2022031218143404900_B15) 2003; 60 Despres (2022031218143404900_B21) 1993; 6 Buchanan (2022031218143404900_B7) 2002; 51 Weyer (2022031218143404900_B22) 1999; 104 Walker (2022031218143404900_B8) 2005; 48 Knowler (2022031218143404900_B2) 2002; 346 Mathews (2022031218143404900_B13) 1985; 28 Abate (2022031218143404900_B9) 2007; 125 World Health Organization (2022031218143404900_B12) 1999 Festa (2022031218143404900_B18) 2006; 55 The DREAM (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication) Trial Investigators (2022031218143404900_B6) 2006; 368 Snehalatha (2022031218143404900_B10) 1999; 16 Matsuda (2022031218143404900_B24) 1997; 46 Li (2022031218143404900_B4) 2008; 371 Pan (2022031218143404900_B3) 1997; 20 Korytkowski (2022031218143404900_B25) 1995; 44 Wareham (2022031218143404900_B14) 1995; 12 UK Prospective Diabetes Study Group (2022031218143404900_B11) 1995; 44 The Diabetes Prevention Program Research Group (2022031218143404900_B19) 2005; 54 Ramachandran (2022031218143404900_B5) 2006; 49 Snehalatha (2022031218143404900_B16) 1999; 16 Saad (2022031218143404900_B23) 1988; 319 Unwin (2022031218143404900_B17) 2002; 19 Uusuitupa (2022031218143404900_B20) 2003; 52 |
| References_xml | – volume: 12 start-page: 931 year: 1995 ident: 2022031218143404900_B14 article-title: The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion publication-title: Diabet Med doi: 10.1111/j.1464-5491.1995.tb00399.x – volume: 51 start-page: 2769 year: 2002 ident: 2022031218143404900_B7 article-title: Preservation of pancreatic β-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women publication-title: Diabetes doi: 10.2337/diabetes.51.9.2796 – volume: 44 start-page: 1121 year: 1995 ident: 2022031218143404900_B25 article-title: Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose publication-title: Metabolism doi: 10.1016/0026-0495(95)90003-9 – volume: 28 start-page: 412 year: 1985 ident: 2022031218143404900_B13 article-title: Homeostatis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 49 start-page: 289 year: 2006 ident: 2022031218143404900_B5 article-title: The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1) publication-title: Diabetologia doi: 10.1007/s00125-005-0097-z – volume-title: Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus year: 1999 ident: 2022031218143404900_B12 – volume: 371 start-page: 1783 year: 2008 ident: 2022031218143404900_B4 article-title: The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study publication-title: Lancet doi: 10.1016/S0140-6736(08)60766-7 – volume: 319 start-page: 1500 year: 1988 ident: 2022031218143404900_B23 article-title: The natural history of impaired glucose tolerance in the Pima Indians publication-title: N Engl J Med doi: 10.1056/NEJM198812083192302 – volume: 368 start-page: 1096 year: 2006 ident: 2022031218143404900_B6 article-title: Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomized controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(06)69420-8 – volume: 16 start-page: 19 year: 1999 ident: 2022031218143404900_B10 article-title: Insulin resistance in Asians Indians publication-title: Prac Diabetes Int doi: 10.1002/pdi.1960160112 – volume: 46 start-page: 68A year: 1997 ident: 2022031218143404900_B24 article-title: Relationship between insulin sensitivity in adipose tissue, liver, muscle and components of the insulin resistance syndrome (Abstract) publication-title: Diabetes – volume: 52 start-page: 2532 year: 2003 ident: 2022031218143404900_B20 article-title: Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study publication-title: Diabetes doi: 10.2337/diabetes.52.10.2532 – volume: 6 start-page: 137 year: 1993 ident: 2022031218143404900_B21 article-title: Effects of diet and physical activity on adiposity and body fat distribution: implications for the prevention of cardiovascular disease publication-title: Nutr Res Rev doi: 10.1079/NRR19930010 – volume: 60 start-page: 199 year: 2003 ident: 2022031218143404900_B15 article-title: Metabolic syndrome in urban Asian Indian adults—a population study using modified ATP III criteria publication-title: Diabetes Res Clin Pract doi: 10.1016/S0168-8227(03)00060-3 – volume: 54 start-page: 2404-2414 year: 2005 ident: 2022031218143404900_B19 article-title: Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the Diabetes Prevention Program: effects of lifestyle intervention and metformin publication-title: Diabetes doi: 10.2337/diabetes.54.8.2404 – volume: 55 start-page: 1114 year: 2006 ident: 2022031218143404900_B18 article-title: The natural course of β-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study publication-title: Diabetes doi: 10.2337/diabetes.55.04.06.db05-1100 – volume: 19 start-page: 708 year: 2002 ident: 2022031218143404900_B17 article-title: Impaired glucose tolerance and impaired fasting glycemia: the current status on definition and intervention publication-title: Diabet Med doi: 10.1046/j.1464-5491.2002.00835.x – volume: 48 start-page: 2470 year: 2005 ident: 2022031218143404900_B8 article-title: Impaired β-cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects publication-title: Diabetologia doi: 10.1007/s00125-005-0004-7 – volume: 104 start-page: 787 year: 1999 ident: 2022031218143404900_B22 article-title: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus publication-title: J Clin Invest doi: 10.1172/JCI7231 – volume: 16 start-page: 408 year: 1999 ident: 2022031218143404900_B16 article-title: Insulin secretion and action in different stages of glucose tolerance in Asian Indians publication-title: Diabet Med doi: 10.1046/j.1464-5491.1999.00084.x – volume: 20 start-page: 537 year: 1997 ident: 2022031218143404900_B3 article-title: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: The Da Qing IGT and Diabetes Study publication-title: Diabetes Care doi: 10.2337/diacare.20.4.537 – volume: 44 start-page: 1249 year: 1995 ident: 2022031218143404900_B11 article-title: UK Prospective Diabetes Study 16: overview of 6 years' therapy of type 2 diabetes: a progressive disease publication-title: Diabetes doi: 10.2337/diab.44.11.1249 – volume: 346 start-page: 393 year: 2002 ident: 2022031218143404900_B2 article-title: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin publication-title: N Engl J Med doi: 10.1056/NEJMoa012512 – volume: 125 start-page: 251 year: 2007 ident: 2022031218143404900_B9 article-title: Ethnicity, type 2 diabetes and migrant Asian Indians publication-title: Indian J Med Res – volume: 344 start-page: 1343 year: 2001 ident: 2022031218143404900_B1 article-title: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance publication-title: N Engl J Med doi: 10.1056/NEJM200105033441801 |
| SSID | ssj0004488 |
| Score | 2.160644 |
| Snippet | OBJECTIVE: The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of... Changes in Insulin Secretion and Insulin Sensitivity in Relation to the Glycemic Outcomes in Subjects With Impaired Glucose Tolerance in the Indian Diabetes... The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in... |
| SourceID | pubmedcentral proquest gale pubmed pascalfrancis crossref highwire fao |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1796 |
| SubjectTerms | Adult Analysis anthropometric measurements Biological and medical sciences blood glucose Changes Dextrose Diabetes Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - prevention & control Diabetes Mellitus, Type 2 - therapy Diabetes. Impaired glucose tolerance drug therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance fasting Female Glucose Glucose Intolerance Glucose Intolerance - drug therapy Glucose Intolerance - physiopathology glucose tolerance homeostasis Humans Hypoglycemic Agents Hypoglycemic Agents - therapeutic use Insulin Insulin - metabolism insulin resistance Insulin Resistance - physiology Insulin Secretion Intervention lifestyle Male Medical sciences Metabolic diseases metabolism metformin Metformin - therapeutic use Middle Aged Minority & ethnic groups Miscellaneous Original Research physiology physiopathology Plasma prevention & control Public health. Hygiene Public health. Hygiene-occupational medicine risk secretion Statistical analysis Studies therapeutic use therapy Treatment Outcome |
| Title | Changes in Insulin Secretion and Insulin Sensitivity in Relation to the Glycemic Outcomes in Subjects With Impaired Glucose Tolerance in the Indian Diabetes Prevention Programme-1 (IDPP-1) |
| URI | http://care.diabetesjournals.org/content/32/10/1796.abstract https://www.ncbi.nlm.nih.gov/pubmed/19587369 https://www.proquest.com/docview/223037778 https://www.proquest.com/docview/46406908 https://www.proquest.com/docview/733599759 https://pubmed.ncbi.nlm.nih.gov/PMC2752907 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELfYJiFeEN8rG8VCE4yHaEns2MkTGmNjBW0Utmp9sxzH3iqVZJD2gf-NP467fLQNKrxUbf1T4o-789n--Y6QPR06K7XRXpCYyOOw6PC0jIQXMhk7nmnpqnQ-Z-fidMQ_jaNxw80pG1plaxMrQ50VBvfID2Aa85mUMn53-8PDpFF4uNpk0NggWxi5DBldciyX1yJ5lXYSFwFelCRhHVgoZEweZAbPBARGGlmZjjacLpamuY0XjHRJXUKPuTrVxTpf9G9K5cocdfKA3G-cS3pYS8NDcsfmj8jds-b4_DH5Xd8lKOkkp4OahE4v0G_E0aE6z1b-zZHMhYklENxS5uisoOAx0o_TXwZZ9fTLfAbdVz8RbBBu6pT0ajK7oQOwM9CsDLAVKZ5eFlOLTbOIxYcMcpRN2nByStpGk4LXDGvW2HfrBXR_8GE49IK3T8jo5Pjy6NRr0jd4JoJ539POd1mS-kxnzrCAyyzWNuHWQmkqdSbTLHZOC-4yq-MUZkoBFiVlmXEGFkWcPSWbeZHbbUITAV4sB88nwOWbtJo7A36Vz3UUSSP8HtlvR1GZJrY5ptiYKljj4IArHHCFA94jrxbQ2zqgxzrQNoiC0tdgaNXoIsTj3UDE4DsmPfIG5UOh_sMrjG6uMUBFMZKWOoQ1NBN4YblHXneQ13Uc8XXA3Q4QFNx0ivdaUVTthjx-QWqgYiHWHqwq1LnfEdNF60LkEkkBgJ1WblVjqEq1UKseebkoxQog9y63xbxUXODtaB8Q9B8IyRjol4ygc57VarDsWlBLyQSUyI6CLAAY3rxbkk9uqjDnoYzCxJfP_1vtHXKvOt-r6JW7ZHP2c25fgJs4S_uVMYDP-Cjok633x-fDb_Dr89f4Dx0Baoo |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELe2TgJeEP9XNjYLDRgP0dLYiZMHhAbbaNk6KtaKvRnXsbdKJRmkFdqH4hvw4bjLn7ZBhbe9VfXJsXPn813ud3eE7CjPGqG0clqR9h0OToejhB84HhOh5bESNm_n0z0N2gP-8dw_XyG_qlwYhFVWOjFX1HGq8Rv5HlxjLhNChG-vvjvYNAqDq1UHjUIqjs31T_DYsjedA2DvC887Ouy_bztlUwFH-3AbOcq6No6GLlOx1azFRRwqE3FjYHQoVCyGcWitCriNjQqHoL8DkPMhi7XVYKpzBvOukjXOwJNpkLV3h6e9z_NETJ43ukS3w_GjyCtKGXmMib1YYxQiwNomCxfgqlXp_DKoKhQjQFNlwCNbNNdYZv3-DeJcuBWP7pG7pTlL9wv5u09WTPKA3OqWAfuH5HeRvZDRUUI7BeydnqGlivJAVRIv_JsgfAxbWSBxBdKjk5SCjUo_jK814vjpp-kEGFbMCFoPPyNl9Mtockk7oNlgWzHQ5jB82k_HBrdmkBYn6SR4GmiJAspoVb8KHtMrcGrfjNOiu52DXs9pvX5EBjfC28ekkaSJWSc0CsBu5mBrtdBhFEZxq8GSc7nyfaEDt0l2Ky5KXVZTx6YeYwleFTJcIsMlMrxJns9Ir4oSIsuI1kEUpLoA1S4HZx4GlFtBCNZq1CSvUD4kahx4hFZl4gQsFGt3yX3w2lmAKdJN8rJGeVFULl9GuFkjBJWia8M7lSjKKgSAPxCMKJmHqwc9DmveqonpbHceopdEAAQbldzKUjVmcnaQm2R7NooLQLRfYtJpJnmA-dguUNB_UAjG4HwJH17Ok-IYzF9t5IeCBTAiagdkRoAF1esjyegyL6zuCd-LXPH0v8veJrfb_e6JPOmcHm-QO3l0MQd3bpLG5MfUPAMjdTLcKlUDJV9vWhv9AWmjp5s |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe2IU28IL5XNjYLDRgPUZM4iZMHhCZKWRgblbZqfTOOY2-VSjJIK7Q_DYk_jrt8tA0qvO2tqk-OnTv_fBf_fEfIvnSN5lJJy4mUb3kQdFiS-4HlMh4aL5XclOV8Tk6Do6H3aeSP1siv5i4M0iobTCyBOs0VfiPvwjZmM8552DU1K2LQ67-7_m5hASk8aG2qaVQWcqxvfkL0VryNe6Dql67b_3D-_siqCwxYyoedyZLGNmmU2EymRjHH42kodeRpDa0JlylP0tAYGXgm1TJMAMsDsPmEpcoocNs9Bv2ukzuc-Q4uMT7iiyuZXlnyEgMQy48it0pq5DLGu6nC84gAs5wsbYXrRuaLbaHJVYxUTVmAtkxVZmOVH_w3nXNpf-zfJ_dqx5YeVpb4gKzp7CHZPKmP7h-R39U9hoKOMxpXBHh6hj4rWgaVWbr0b4ZEMixqgcINXY9OcwreKv04uVHI6KdfZlNQXdUj4B9-UCroxXh6RWPAOJhWCrIlIZ-e5xONU9Moi53EGa4LWvOBCtpksoLHDCrG2jdtOfQg7g0GlvPmMRneimafkI0sz_QWoVEAHrQHXpeDoSPX0jMKfDrbk77PVWB3yEGjRaHqvOpY3mMiIL5ChQtUuECFd8iLueh1lUxkldAWmIKQlwDyYnjm4tGyE4Tgt0Yd8hrtQyD2wCOUrK9QwEAxi5c4hPidBXhZukNetSQvqxzmqwR3WoIALqrVvN-YomgOA_AH0hIFc3H0gOgw5t2Wmc5n5yKPiQcgsN3YrahBshDzJd0he_NWHADy_jKdzwrhBXgz2wYJ-g8JzhisL-7Dy3laLYPFq438kLMAWnhrgcwFMLV6uyUbX5Up1l3uu5HNn_132HtkEzBIfI5Pj7fJ3fKYsWR57pCN6Y-Zfg7e6jTZLXGBkq-3DUR_ACKWqms |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Changes+in+insulin+secretion+and+insulin+sensitivity+in+relation+to+the+glycemic+outcomes+in+subjects+with+impaired+glucose+tolerance+in+the+Indian+Diabetes+Prevention+Programme-1+%28IDPP-1%29&rft.jtitle=Diabetes+care&rft.au=Snehalatha%2C+Chamukuttan&rft.au=Mary%2C+Simon&rft.au=Selvam%2C+Sundaram&rft.au=Sathish+Kumar%2C+Cholaiyil+Kizhakathil&rft.date=2009-10-01&rft.eissn=1935-5548&rft.volume=32&rft.issue=10&rft.spage=1796&rft_id=info:doi/10.2337%2Fdc09-0676&rft_id=info%3Apmid%2F19587369&rft.externalDocID=19587369 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0149-5992&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0149-5992&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0149-5992&client=summon |