Human Adipose‐Derived Stromal/Stem Cells Protect Against STZ‐Induced Hyperglycemia: Analysis of hASC‐Derived Paracrine Effectors

• Published in: Stem cells (Dayton, Ohio) Vol. 32; no. 7; pp. 1831 - 1842
• Main Authors: Kono, Tatsuyoshi M., Sims, Emily K., Moss, Dan R., Yamamoto, Wataru, Ahn, Geonyoung, Diamond, Julie, Tong, Xin, Day, Kathleen H., Territo, Paul R., Hanenberg, Helmut, Traktuev, Dmitry O., March, Keith L., Evans‐Molina, Carmella
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2014
• Subjects: Adipose stem cells; Adult; Adult Stem Cells - metabolism; Adult Stem Cells - transplantation; Animals; Caspase; Cell Size; Cells, Cultured; Cellular proliferation; Coculture Techniques; Cytokines - physiology; Diabetes; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - therapy; Diabetes Mellitus, Type 1 - chemically induced; Diabetes Mellitus, Type 1 - therapy; Female; Glucose Intolerance; Humans; Hyperglycemia; Hyperglycemia - chemically induced; Hyperglycemia - therapy; Insulin-Secreting Cells - pathology; Male; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Pancreas; Paracrine Communication; Rodents; Stem cells; Streptozocin; Subcutaneous Fat - cytology; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tissue regeneration; Caspase; Diabetes; Cellular proliferation; Pancreas; Tissue regeneration; Adipose stem cells

Adipose‐derived stromal/stem cells (ASCs) ameliorate hyperglycemia in rodent models of islet transplantation and autoimmune diabetes, yet the precise human ASC (hASC)‐derived factors responsible for these effects remain largely unexplored. Here, we show that systemic administration of hASCs improved...