Scientific research progress of COVID‐19/SARS‐CoV‐2 in the first five months

A cluster of pneumonia (COVID‐19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2), which has a phylogenetic simila...

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Published inJournal of cellular and molecular medicine Vol. 24; no. 12; pp. 6558 - 6570
Main Authors Li, Hua, Liu, Zhe, Ge, Junbo
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.06.2020
John Wiley and Sons Inc
Subjects
Adenosine Monophosphate - analogs & derivatives
Adenosine Monophosphate - therapeutic use
Age
Alanine - analogs & derivatives
Alanine - therapeutic use
Amides - therapeutic use
Amino acids
Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antiviral Agents - therapeutic use
Asymptomatic
Betacoronavirus - drug effects
Betacoronavirus - immunology
Betacoronavirus - pathogenicity
Chronic illnesses
Clinical Laboratory Techniques
Coronaviridae
Coronavirus Infections - diagnosis
Coronavirus Infections - drug therapy
Coronavirus Infections - epidemiology
Coronavirus Infections - immunology
Coronavirus Infections - prevention & control
Coronavirus Infections - therapy
Coronaviruses
COVID-19
COVID-19 Serotherapy
COVID-19 Testing
COVID-19 Vaccines
Disease Progression
Disease transmission
Epidemics
Epidemiology
Fatalities
Gene Expression Regulation
Genomes
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Immunization, Passive - methods
Infections
Medical research
Mutation
Pandemics
Pathogenesis
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - immunology
Phylogenetics
Phylogeny
Pneumonia, Viral - diagnosis
Pneumonia, Viral - drug therapy
Pneumonia, Viral - epidemiology
Pneumonia, Viral - immunology
Proteins
Pyrazines - therapeutic use
Review
Reviews
Ribonucleic acid
RNA
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Spike Glycoprotein, Coronavirus - antagonists & inhibitors
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - immunology
Studies
Viral infections
Viral Vaccines - biosynthesis
Viruses
United Kingdom > UK
China
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Abstract A cluster of pneumonia (COVID‐19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2), which has a phylogenetic similarity to severe acute respiratory syndrome coronavirus (SARS‐CoV). SARS‐CoV‐2 transmits mainly through droplets and close contact and the elder or people with chronic diseases are high‐risk population. People affected by SARS‐CoV‐2 can be asymptomatic, which brings about more difficulties to control the transmission. COVID‐19 has become pandemic rapidly after onset, and so far the infected people have been above 2 000 000 and more than 130 000 died worldwide according to COVID‐19 situation dashboard of World Health Organization (https://covid19.who.int). Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID‐19/ SARS‐CoV‐2 as reference for the prevention and control COVID‐19.
AbstractList A cluster of pneumonia (COVID‐19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2), which has a phylogenetic similarity to severe acute respiratory syndrome coronavirus (SARS‐CoV). SARS‐CoV‐2 transmits mainly through droplets and close contact and the elder or people with chronic diseases are high‐risk population. People affected by SARS‐CoV‐2 can be asymptomatic, which brings about more difficulties to control the transmission. COVID‐19 has become pandemic rapidly after onset, and so far the infected people have been above 2 000 000 and more than 130 000 died worldwide according to COVID‐19 situation dashboard of World Health Organization (https://covid19.who.int). Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID‐19/ SARS‐CoV‐2 as reference for the prevention and control COVID‐19.
A cluster of pneumonia (COVID-19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), which has a phylogenetic similarity to severe acute respiratory syndrome coronavirus (SARS-CoV). SARS-CoV-2 transmits mainly through droplets and close contact and the elder or people with chronic diseases are high-risk population. People affected by SARS-CoV-2 can be asymptomatic, which brings about more difficulties to control the transmission. COVID-19 has become pandemic rapidly after onset, and so far the infected people have been above 2 000 000 and more than 130 000 died worldwide according to COVID-19 situation dashboard of World Health Organization (https://covid19.who.int). Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19.
A cluster of pneumonia (COVID‐19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2), which has a phylogenetic similarity to severe acute respiratory syndrome coronavirus (SARS‐CoV). SARS‐CoV‐2 transmits mainly through droplets and close contact and the elder or people with chronic diseases are high‐risk population. People affected by SARS‐CoV‐2 can be asymptomatic, which brings about more difficulties to control the transmission. COVID‐19 has become pandemic rapidly after onset, and so far the infected people have been above 2 000 000 and more than 130 000 died worldwide according to COVID‐19 situation dashboard of World Health Organization ( https://covid19.who.int ). Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID‐19/ SARS‐CoV‐2 as reference for the prevention and control COVID‐19.
A cluster of pneumonia (COVID-19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), which has a phylogenetic similarity to severe acute respiratory syndrome coronavirus (SARS-CoV). SARS-CoV-2 transmits mainly through droplets and close contact and the elder or people with chronic diseases are high-risk population. People affected by SARS-CoV-2 can be asymptomatic, which brings about more difficulties to control the transmission. COVID-19 has become pandemic rapidly after onset, and so far the infected people have been above 2 000 000 and more than 130 000 died worldwide according to COVID-19 situation dashboard of World Health Organization (https://covid19.who.int). Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19.A cluster of pneumonia (COVID-19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), which has a phylogenetic similarity to severe acute respiratory syndrome coronavirus (SARS-CoV). SARS-CoV-2 transmits mainly through droplets and close contact and the elder or people with chronic diseases are high-risk population. People affected by SARS-CoV-2 can be asymptomatic, which brings about more difficulties to control the transmission. COVID-19 has become pandemic rapidly after onset, and so far the infected people have been above 2 000 000 and more than 130 000 died worldwide according to COVID-19 situation dashboard of World Health Organization (https://covid19.who.int). Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19.
Author Li, Hua
Liu, Zhe
Ge, Junbo
AuthorAffiliation 2 Department of Medicine BestNovo (Beijing) Medical Technology Co., Ltd Beijing China
1 Department of Cardiology Shanghai Institute of Cardiovascular Diseases Shanghai Xuhui District Central Hospital and Zhongshan‐Xuhui Hospital Zhongshan Hospital Fudan University Shanghai China
AuthorAffiliation_xml – name: 1 Department of Cardiology Shanghai Institute of Cardiovascular Diseases Shanghai Xuhui District Central Hospital and Zhongshan‐Xuhui Hospital Zhongshan Hospital Fudan University Shanghai China
– name: 2 Department of Medicine BestNovo (Beijing) Medical Technology Co., Ltd Beijing China
Author_xml – sequence: 1
  givenname: Hua
  orcidid: 0000-0001-9644-6768
  surname: Li
  fullname: Li, Hua
  email: lihua199988@hotmail.com
  organization: Fudan University
– sequence: 2
  givenname: Zhe
  surname: Liu
  fullname: Liu, Zhe
  organization: BestNovo (Beijing) Medical Technology Co., Ltd
– sequence: 3
  givenname: Junbo
  surname: Ge
  fullname: Ge, Junbo
  email: ge.junbo@zs-hospital.sh.cn
  organization: Fudan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32320516$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2020 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Snippet A cluster of pneumonia (COVID‐19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded...
A cluster of pneumonia (COVID-19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded...
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SubjectTerms Adenosine Monophosphate - analogs & derivatives
Adenosine Monophosphate - therapeutic use
Age
Alanine - analogs & derivatives
Alanine - therapeutic use
Amides - therapeutic use
Amino acids
Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antiviral Agents - therapeutic use
Asymptomatic
Betacoronavirus - drug effects
Betacoronavirus - immunology
Betacoronavirus - pathogenicity
Chronic illnesses
Clinical Laboratory Techniques
Coronaviridae
Coronavirus Infections - diagnosis
Coronavirus Infections - drug therapy
Coronavirus Infections - epidemiology
Coronavirus Infections - immunology
Coronavirus Infections - prevention & control
Coronavirus Infections - therapy
Coronaviruses
COVID-19
COVID-19 Serotherapy
COVID-19 Testing
COVID-19 Vaccines
Disease Progression
Disease transmission
Epidemics
Epidemiology
Fatalities
Gene Expression Regulation
Genomes
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Immunization, Passive - methods
Infections
Medical research
Mutation
Pandemics
Pathogenesis
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - immunology
Phylogenetics
Phylogeny
Pneumonia, Viral - diagnosis
Pneumonia, Viral - drug therapy
Pneumonia, Viral - epidemiology
Pneumonia, Viral - immunology
Proteins
Pyrazines - therapeutic use
Review
Reviews
Ribonucleic acid
RNA
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Spike Glycoprotein, Coronavirus - antagonists & inhibitors
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - immunology
Studies
Viral infections
Viral Vaccines - biosynthesis
Viruses
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