Using adipose‐derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?

Summary Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell‐based therapies have become a promising tool for therapeutic intervention. Among them are adipose‐derived mesenchymal stem cells (ADMSCs), secreting numerous bio...

Full description

Saved in:
Bibliographic Details
Published inObesity reviews Vol. 23; no. 5; pp. e13413 - n/a
Main Authors Mikłosz, Agnieszka, Nikitiuk, Barbara Emilia, Chabowski, Adrian
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.05.2022
John Wiley and Sons Inc
Subjects
adipose tissue
Adipose Tissue - metabolism
ADMSCs
Animal models
Animals
Autografts
Cell viability
Chemokines
Cirrhosis
Clinical trials
Cytokines
Cytokines - metabolism
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Dyslipidemia
Graft rejection
Growth factors
Humans
Hyperglycemia
hyperlipidemia
Immunomodulation
immunosuppression
Inflammation
Insulin
insulin resistance
islets of Langerhans
Liver
Liver cirrhosis
liver function
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Metabolic Diseases - metabolism
Metabolic disorders
Metabolic syndrome
Metabolism
noninsulin-dependent diabetes mellitus
Obesity
Obesity - complications
Obesity - metabolism
Obesity - therapy
Obesity Comorbidities/Treatment
Oxidative stress
Recovery of function
Risk analysis
Risk factors
Stem cell transplantation
Stem cells
therapeutics
Transplantation
metabolic syndrome
adipose tissue
ADMSCs
obesity
Online AccessGet full text

Cover

Abstract Summary Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell‐based therapies have become a promising tool for therapeutic intervention. Among them are adipose‐derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro‐inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
AbstractList Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell-based therapies have become a promising tool for therapeutic intervention. Among them are adipose-derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro-inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell-based therapies have become a promising tool for therapeutic intervention. Among them are adipose-derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro-inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
Summary Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell‐based therapies have become a promising tool for therapeutic intervention. Among them are adipose‐derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro‐inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell‐based therapies have become a promising tool for therapeutic intervention. Among them are adipose‐derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro‐inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
Author Chabowski, Adrian
Nikitiuk, Barbara Emilia
Mikłosz, Agnieszka
AuthorAffiliation 1 Department of Physiology Medical University of Bialystok Bialystok Poland
AuthorAffiliation_xml – name: 1 Department of Physiology Medical University of Bialystok Bialystok Poland
Author_xml – sequence: 1
  givenname: Agnieszka
  orcidid: 0000-0003-4936-3120
  surname: Mikłosz
  fullname: Mikłosz, Agnieszka
  email: agnieszka.miklosz@umb.edu.pl
  organization: Medical University of Bialystok
– sequence: 2
  givenname: Barbara Emilia
  surname: Nikitiuk
  fullname: Nikitiuk, Barbara Emilia
  organization: Medical University of Bialystok
– sequence: 3
  givenname: Adrian
  surname: Chabowski
  fullname: Chabowski, Adrian
  organization: Medical University of Bialystok
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34985174$$D View this record in MEDLINE/PubMed
BookMark eNqNkttqVDEUhoNU7EEvfAEJeKMX0yY7h73jhaLFExQKYtG7kJ2sPZOydzImmZa58xF8Rp_EtDMtWhTMzQrk-3_W-rP20U6IARB6TMkhreco9umQMk7ZPbRHuWxnbae-7tzeO7qL9nM-J4S2itEHaJdx1Qna8j2UzrIPc2ycX8YMP7__cJD8BTg8QYZgF-vJjDgXmLCFccy4RDz4-aLgsoDKFNPH0Vts47Ss1RQfQ8ZxwLGH7Mv6Bf6ygATYRXwJ1ccE9-ohuj-YMcOjbT1AZ-_efj7-MDs5ff_x-PXJzAresFlP2NAOnFBhG0UH4eTQUutAcM4YJX2dC1xLrGi4Zb00YKWivaBOKaKEpewAvdz4Llf9BM5CKMmMepn8ZNJaR-P1ny_BL_Q8XmjVdKKjrBo82xqk-G0FuejJ56sYTIC4yrqRkhIhZCv_A6VSScKbpqJP76DncZVCTaJSvFOCK0Iq9eT35m-7vvm5ChxtAJtizgkGbX25zr_O4kdNib7aDV13Q1_vRlU8v6O4Mf0bu3W_9COs_w3q0zefNopf_ejJ9A
CitedBy_id crossref_primary_10_1186_s13287_024_04034_2
crossref_primary_10_3390_biom15030422
crossref_primary_10_1016_j_jep_2024_118985
crossref_primary_10_1111_1753_0407_13465
crossref_primary_10_1016_j_intimp_2024_112821
crossref_primary_10_1186_s13287_023_03359_8
crossref_primary_10_1007_s11033_023_08877_5
crossref_primary_10_3390_cells11091435
crossref_primary_10_3390_ijms24032310
crossref_primary_10_1172_jci_insight_181339
crossref_primary_10_1002_cbdv_202200670
crossref_primary_10_3390_ijms232315339
crossref_primary_10_1007_s12015_024_10755_x
crossref_primary_10_1038_s41588_024_02052_7
crossref_primary_10_1002_advs_202207334
crossref_primary_10_3389_fcell_2022_1002909
crossref_primary_10_3390_ijms241310672
crossref_primary_10_1002_cmdc_202400611
crossref_primary_10_1016_j_arr_2023_101852
crossref_primary_10_3390_ijms23094900
crossref_primary_10_1210_clinem_dgad142
crossref_primary_10_1111_dom_15375
crossref_primary_10_1155_2023_2883623
crossref_primary_10_4239_wjd_v14_i3_347
crossref_primary_10_3389_fmolb_2023_1232159
crossref_primary_10_1007_s44164_024_00076_1
Cites_doi 10.1161/CIRCRESAHA.121.318093
10.1161/01.CIR.0000121425.42966.F1
10.1038/s41366-019-0438-5
10.1186/s13287-019-1310-1
10.1007/s00018-018-2859-z
10.1038/kisup.2011.24
10.3892/ijmm.2015.2413
10.1161/01.ATV.20.6.1595
10.5604/01.3001.0010.3829
10.1016/j.atherosclerosis.2014.02.033
10.1038/srep37801
10.1126/science.1104345
10.1155/2019/7921760
10.1038/ijo.2010.235
10.1016/j.cdtm.2017.02.008
10.1136/gutjnl-2012-302152
10.1111/j.1467-789X.2012.01032.x
10.1152/ajpendo.00586.2009
10.1634/stemcells.2008-0034
10.1016/j.reth.2016.12.001
10.1111/j.1743-6109.2006.00128.x
10.3389/fimmu.2021.650768
10.3390/nu13072459
10.1016/j.bbrc.2014.11.122
10.1186/s13287-017-0743-7
10.1136/gut.2006.111617
10.1097/CCM.0b013e31823dae23
10.1177/1535370219839643
10.1371/journal.pone.0020615
10.1016/j.jcyt.2016.07.006
10.2337/db14-1042
10.3390/cells8050462
10.1038/292154a0
10.1186/s13287-019-1474-8
10.1155/2017/1653254
10.1371/journal.pone.0241993
10.1093/cvr/cvy271
10.1007/s12020-013-0087-8
10.1089/ten.tea.2014.0115
10.1016/j.bbrc.2016.12.125
10.1530/JOE-13-0201
10.1111/obr.12157
10.1038/nature06902
10.4103/2230-8210.94264
10.4239/wjd.v10.i5.280
10.1016/j.biopha.2021.111315
10.1016/j.reth.2020.03.012
10.1387/ijdb.092953hk
10.1634/stemcells.2005-0542
10.1007/s40519-018-0481-6
10.1016/j.bbrc.2013.10.059
10.1111/jgh.14647
10.1002/stem.117
10.1016/j.ejphar.2020.173215
10.3390/ijms15057352
10.1016/j.stem.2012.08.013
10.1016/j.jhep.2011.02.020
10.1016/j.jcyt.2013.01.005
10.1016/j.metabol.2004.09.006
10.1038/s41598-019-56835-8
10.1080/14653240600855905
10.3727/096368912X657215
10.1016/j.jacc.2009.06.055
10.1155/2014/720753
10.1007/s00125-013-3066-y
10.1016/j.cmet.2008.04.004
10.1002/path.4133
10.1016/j.metabol.2018.11.009
10.1186/s13287-015-0201-3
10.1002/hep.26470
10.1371/journal.pone.0113936
10.1038/s41598-021-85917-9
10.1002/cyto.a.22402
10.1111/j.1467-789X.2009.00623.x
10.1093/humrep/dew041
10.1016/j.jcyt.2013.02.006
10.1111/obr.12198
10.1016/j.lfs.2018.10.054
10.1089/107632701300062859
10.3892/mmr.2015.3847
10.1186/1471-2164-14-625
10.1016/j.jcyt.2013.07.011
10.1177/1535370216681552
10.1016/j.bbrc.2006.01.072
10.3390/nu13062101
10.3390/ijms22147644
10.1152/ajpregu.00280.2006
10.1097/01.ogx.0000338100.83483.58
10.1016/j.imlet.2009.07.010
10.1097/SLA.0000000000001155
10.1002/stem.127
10.1371/journal.pone.0010088
10.1016/j.trsl.2016.11.003
10.1111/liv.13301
10.1007/978-1-61779-468-1_17
10.1007/s00592-015-0715-2
10.1155/2018/7318513
10.1038/mt.2011.211
10.1152/ajpheart.01071.2003
10.1007/s10529-011-0541-8
10.1186/s13287-017-0716-x
10.1038/ijo.2010.216
10.3892/ijmm.2014.1821
10.1016/j.biopha.2016.10.086
10.1186/s13287-019-1393-8
10.1016/0888-7543(91)90032-A
10.1083/jcb.201409063
10.3390/biom11070918
10.1016/S0140-6736(16)31203-X
10.1371/journal.pcbi.1000324
10.1007/s00125-002-1009-0
10.3390/cells10061515
10.1002/stem.430
10.1038/nature05485
10.1136/gut.2008.154880
10.3390/ijms22136900
10.1016/j.ymthe.2018.06.013
10.1111/j.1753-4887.2011.00456.x
10.1038/mt.2011.189
10.5966/sctm.2015-0239
10.1385/ENDO:29:1:81
10.1038/s41591-018-0104-9
10.1016/j.stem.2012.05.015
10.1152/ajpcell.00437.2007
10.1016/j.cpcardiol.2006.03.001
10.1053/meta.2001.27213
10.1097/MEG.0b013e32832a1f6c
10.1089/ars.2018.7626
10.1111/j.1440-1746.2008.05496.x
10.1038/s41430-021-00942-1
10.1126/science.282.5391.1145
10.1507/endocrj.EJ14-0584
10.4174/jkss.2011.81.3.176
10.1038/srep00081
10.1161/01.RES.0000265074.83288.09
10.1016/j.cytogfr.2009.10.002
10.1186/s12958-015-0104-2
10.1002/jcb.25777
10.1186/s13287-015-0181-3
10.2147/DMSO.S223618
10.2174/1574888X13666180515160008
10.1089/scd.2019.0250
10.1002/jbt.21919
10.3390/nu13072254
10.1161/ATVBAHA.109.187179
ContentType Journal Article
Copyright 2022 The Authors. published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2022 The Authors. published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
– notice: 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
– notice: 2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID 24P
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T2
7TS
C1K
K9.
NAPCQ
7X8
7S9
L.6
5PM
DOI 10.1111/obr.13413
DatabaseName Wiley Online Library Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Health and Safety Science Abstracts (Full archive)
Physical Education Index
Environmental Sciences and Pollution Management
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
Health & Safety Science Abstracts
Physical Education Index
Environmental Sciences and Pollution Management
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic


AGRICOLA
MEDLINE
ProQuest Health & Medical Complete (Alumni)
CrossRef
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley Online Library Open Access
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitleAlternate Mikłosz et al
EISSN 1467-789X
EndPage n/a
ExternalDocumentID PMC9285813
34985174
10_1111_obr_13413
OBR13413
Genre reviewArticle
Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: National Science Center
  funderid: 2016/23/D/NZ3/01660
– fundername: Medical University of Bialystok
  funderid: SUB/1/DN/20/010/1118
– fundername: ;
  grantid: SUB/1/DN/20/010/1118
– fundername: ;
  grantid: 2016/23/D/NZ3/01660
GroupedDBID ---
.3N
.GA
.Y3
05W
0R~
10A
123
1OC
24P
29N
31~
33P
36B
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5HH
5LA
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHBH
AAHHS
AAHQN
AAIPD
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABEML
ABJNI
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACRPL
ACSCC
ACXBN
ACXQS
ACYXJ
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZMN
AEEZP
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFEBI
AFFPM
AFGKR
AFPWT
AFRAH
AFWVQ
AFZJQ
AHBTC
AHMBA
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CAG
COF
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBS
EJD
ESX
EX3
F00
F01
F04
F5P
FEDTE
FUBAC
G-S
G.N
GODZA
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
IHE
IX1
J0M
K48
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PQQKQ
Q.N
Q11
QB0
R.K
ROL
RX1
SUPJJ
TEORI
UB1
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WOHZO
WOW
WQJ
WRC
WVDHM
WXI
WXSBR
XG1
YFH
ZZTAW
~IA
~KM
~WT
AAYXX
AEYWJ
AGHNM
AGQPQ
AGYGG
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T2
7TS
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
C1K
K9.
NAPCQ
7X8
7S9
L.6
5PM
ID FETCH-LOGICAL-c5423-b03f7f4015c291f5d6f71cde5443310b788ed70c524c3b6aec691b51d99095c13
IEDL.DBID DR2
ISSN 1467-7881
1467-789X
IngestDate Thu Aug 21 14:14:43 EDT 2025
Fri Jul 11 18:39:28 EDT 2025
Fri Jul 11 02:34:29 EDT 2025
Fri Jul 25 12:15:27 EDT 2025
Wed Feb 19 02:25:49 EST 2025
Tue Jul 01 01:47:52 EDT 2025
Thu Apr 24 23:00:06 EDT 2025
Wed Jan 22 16:32:43 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords metabolic syndrome
adipose tissue
ADMSCs
obesity
Language English
License Attribution
2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5423-b03f7f4015c291f5d6f71cde5443310b788ed70c524c3b6aec691b51d99095c13
Notes Funding information
Medical University of Bialystok, Grant/Award Number: SUB/1/DN/20/010/1118; National Science Center, Grant/Award Number: 2016/23/D/NZ3/01660
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
Funding information Medical University of Bialystok, Grant/Award Number: SUB/1/DN/20/010/1118; National Science Center, Grant/Award Number: 2016/23/D/NZ3/01660
ORCID 0000-0003-4936-3120
OpenAccessLink https://proxy.k.utb.cz/login?url=https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fobr.13413
PMID 34985174
PQID 2648954900
PQPubID 2026813
PageCount 22
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9285813
proquest_miscellaneous_2661055676
proquest_miscellaneous_2616960422
proquest_journals_2648954900
pubmed_primary_34985174
crossref_citationtrail_10_1111_obr_13413
crossref_primary_10_1111_obr_13413
wiley_primary_10_1111_obr_13413_OBR13413
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate May 2022
PublicationDateYYYYMMDD 2022-05-01
PublicationDate_xml – month: 05
  year: 2022
  text: May 2022
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Oxford
– name: Hoboken
PublicationTitle Obesity reviews
PublicationTitleAlternate Obes Rev
PublicationYear 2022
Publisher Wiley Subscription Services, Inc
John Wiley and Sons Inc
Publisher_xml – name: Wiley Subscription Services, Inc
– name: John Wiley and Sons Inc
References 2010; 11
2004; 287
2001; 50
2019; 2019
2019; 92
2006; 31
2019; 10
1991; 11
2013; 62
2007; 100
2016; 388
2016; 31
2020; 15
2011; 55
2020; 14
2006; 291
2012; 16
2012; 13
2016; 37
2012; 11
2012; 10
2016; 263
2013; 58
2017; 71
2006; 24
2010; 28
2018; 214
2003; 46
2014; 16
2014; 15
2008; 26
2006; 29
2010; 5
1998; 282
2012; 20
2009; 126
2006; 444
2010; 34
2019; 8
2019; 9
2011; 1
2019; 31
2013; 229
2015; 52
2019; 34
2011; 81
2008; 57
2014; 2014
2018; 23
2016; 18
2011; 6
2014; 45
2018; 26
2018; 24
1981; 292
2016; 5
2016; 6
2016; 7
2013; 218
2021; 137
2015; 62
2019; 43
2015; 64
2010; 299
2006; 341
2014; 34
2018; 13
2020; 29
2012; 40
2017; 6
2010; 54
2017; 8
2017; 3
2021; 22
2013; 22
2021; 128
2008; 7
2020; 881
2000; 1
2008; 4
2019; 244
2017; 118
2012; 70
2009; 58
2017; 31
2013; 15
2013; 14
2009; 54
2017; 37
2015; 456
2019; 115
2005; 307
2014; 57
2016; 84
2008; 63
2017; 483
2017; 242
2014; 9
2018; 75
2014; 443
2015; 13
2015; 12
2009; 24
2015; 6
2009; 21
2009; 20
2017; 2017
2006; 14
2012; 826
2006; 8
2011; 33
2011; 35
2015; 208
2014; 85
2004; 109
2009; 27
2009; 29
2014; 234
2021; 14
2021; 13
2021; 10
2018; 2018
2021; 12
2021; 11
2001; 7
2021
2015; 21
2019
2018
2017; 182
2005; 54
2009; 5
2008; 453
2008; 294
e_1_2_10_21_1
e_1_2_10_44_1
e_1_2_10_40_1
e_1_2_10_109_1
e_1_2_10_131_1
e_1_2_10_70_1
e_1_2_10_93_1
e_1_2_10_2_1
e_1_2_10_139_1
e_1_2_10_18_1
e_1_2_10_74_1
e_1_2_10_97_1
e_1_2_10_116_1
e_1_2_10_150_1
e_1_2_10_6_1
e_1_2_10_55_1
e_1_2_10_135_1
e_1_2_10_14_1
e_1_2_10_37_1
e_1_2_10_78_1
e_1_2_10_112_1
e_1_2_10_13_1
e_1_2_10_32_1
e_1_2_10_51_1
e_1_2_10_120_1
e_1_2_10_147_1
e_1_2_10_82_1
e_1_2_10_128_1
e_1_2_10_29_1
e_1_2_10_63_1
e_1_2_10_86_1
e_1_2_10_105_1
e_1_2_10_124_1
e_1_2_10_25_1
e_1_2_10_48_1
e_1_2_10_101_1
e_1_2_10_143_1
e_1_2_10_45_1
e_1_2_10_22_1
Choe SS (e_1_2_10_34_1) 2016; 7
e_1_2_10_41_1
e_1_2_10_132_1
e_1_2_10_90_1
e_1_2_10_71_1
e_1_2_10_117_1
e_1_2_10_94_1
e_1_2_10_52_1
e_1_2_10_3_1
e_1_2_10_19_1
e_1_2_10_75_1
e_1_2_10_113_1
e_1_2_10_136_1
e_1_2_10_151_1
e_1_2_10_38_1
e_1_2_10_98_1
e_1_2_10_56_1
e_1_2_10_79_1
e_1_2_10_7_1
e_1_2_10_15_1
e_1_2_10_10_1
e_1_2_10_33_1
Pandian A (e_1_2_10_106_1) 2008; 4
e_1_2_10_121_1
e_1_2_10_144_1
e_1_2_10_148_1
e_1_2_10_60_1
e_1_2_10_129_1
e_1_2_10_83_1
e_1_2_10_64_1
e_1_2_10_102_1
e_1_2_10_125_1
e_1_2_10_140_1
e_1_2_10_49_1
e_1_2_10_87_1
e_1_2_10_26_1
e_1_2_10_68_1
e_1_2_10_23_1
e_1_2_10_46_1
e_1_2_10_69_1
e_1_2_10_42_1
e_1_2_10_110_1
e_1_2_10_91_1
e_1_2_10_72_1
e_1_2_10_95_1
e_1_2_10_118_1
e_1_2_10_4_1
e_1_2_10_53_1
e_1_2_10_137_1
e_1_2_10_16_1
e_1_2_10_39_1
e_1_2_10_76_1
e_1_2_10_99_1
e_1_2_10_114_1
e_1_2_10_152_1
e_1_2_10_8_1
e_1_2_10_57_1
e_1_2_10_133_1
e_1_2_10_58_1
e_1_2_10_11_1
e_1_2_10_119_1
El‐Badawy A (e_1_2_10_67_1) 2016; 6
e_1_2_10_145_1
James R (e_1_2_10_43_1) 2019
e_1_2_10_80_1
e_1_2_10_149_1
e_1_2_10_61_1
e_1_2_10_84_1
e_1_2_10_126_1
e_1_2_10_27_1
e_1_2_10_65_1
e_1_2_10_88_1
e_1_2_10_103_1
e_1_2_10_141_1
e_1_2_10_122_1
e_1_2_10_24_1
e_1_2_10_20_1
e_1_2_10_108_1
e_1_2_10_130_1
e_1_2_10_92_1
e_1_2_10_73_1
e_1_2_10_115_1
e_1_2_10_138_1
e_1_2_10_96_1
e_1_2_10_54_1
e_1_2_10_17_1
e_1_2_10_77_1
e_1_2_10_111_1
e_1_2_10_134_1
e_1_2_10_36_1
e_1_2_10_12_1
e_1_2_10_35_1
e_1_2_10_9_1
e_1_2_10_59_1
e_1_2_10_31_1
e_1_2_10_50_1
Unamuno X (e_1_2_10_30_1) 2018
e_1_2_10_146_1
e_1_2_10_81_1
Blaszczak AM (e_1_2_10_5_1) 2021; 12
e_1_2_10_62_1
e_1_2_10_104_1
e_1_2_10_127_1
e_1_2_10_85_1
e_1_2_10_28_1
e_1_2_10_66_1
e_1_2_10_100_1
Liou L (e_1_2_10_107_1) 2020; 15
e_1_2_10_123_1
e_1_2_10_142_1
e_1_2_10_47_1
e_1_2_10_89_1
References_xml – volume: 7
  start-page: 1
  issue: APR
  year: 2016
  end-page: 16
  article-title: Adipose tissue remodeling: its role in energy metabolism and metabolic disorders
  publication-title: Front Endocrinol (Lausanne)
– volume: 14
  start-page: 625
  issue: 1
  year: 2013
  end-page: 637
  article-title: Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte‐like phenotype
  publication-title: BMC Genomics
– volume: 6
  start-page: 1
  issue: November
  year: 2016
  end-page: 11
  article-title: Adipose stem cells display higher regenerative capacities and more adaptable electro‐kinetic properties compared to bone marrow‐derived mesenchymal stromal cells
  publication-title: Sci Rep
– volume: 291
  start-page: 880
  issue: 4
  year: 2006
  end-page: 884
  article-title: Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF‐I in response to TNF by a p38 MAPK‐dependent mechanism
  publication-title: Am J Physiol Regul Integr Comp Physiol
– volume: 34
  start-page: S18
  issue: S2
  year: 2010
  end-page: S23
  article-title: Open questions about metabolically normal obesity
  publication-title: Int J Obes (Lond)
– volume: 28
  start-page: 1099
  issue: 6
  year: 2010
  end-page: 1106
  article-title: A long‐term follow‐up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke
  publication-title: Stem Cells
– volume: 263
  start-page: 546
  issue: 3
  year: 2016
  end-page: 556
  article-title: Attenuation of postoperative acute liver failure by mesenchymal stem cell treatment due to metabolic implications
  publication-title: Ann Surg
– volume: 58
  start-page: 1133
  issue: 3
  year: 2013
  end-page: 1142
  article-title: Adipose tissue‐derived stem cells as a regenerative therapy for a mouse steatohepatitis‐induced cirrhosis model
  publication-title: Hepatology
– volume: 881
  start-page: 1
  year: 2020
  end-page: 10
  article-title: Conditioned medium of adipose derived mesenchymal stem cells reverse insulin resistance through downregulation of stress induced serine kinases
  publication-title: Eur J Pharmacol
– volume: 29
  start-page: 1723
  issue: 11
  year: 2009
  end-page: 1729
  article-title: Adipose tissue‐derived stem cells: characterization and potential for cardiovascular repair
  publication-title: Arterioscler Thromb Vasc Biol
– volume: 29
  start-page: 81
  issue: 1
  year: 2006
  end-page: 90
  article-title: Adipocyte‐derived hormones, cytokines, and mediators
  publication-title: Endocrine
– volume: 4
  start-page: 1001
  issue: 5
  year: 2008
  end-page: 1009
  article-title: Targeting multiple dyslipidemias with fixed combinations—focus on extended release niacin and simvastatin
  publication-title: Vasc Health Risk Manag
– volume: 50
  start-page: 1499
  issue: 12
  year: 2001
  end-page: 1504
  article-title: Are there persons who are obese, but metabolically healthy?
  publication-title: Metabolism
– volume: 287
  start-page: 5
  issue: 6
  year: 2004
  end-page: 7
  article-title: Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis
  publication-title: Am J Physiol Heart Circ Physiol
– volume: 21
  start-page: 1621
  issue: 9–10
  year: 2015
  end-page: 1632
  article-title: Osteogenic performance of donor‐matched human adipose and bone marrow mesenchymal cells under dynamic culture
  publication-title: Tissue Eng ‐ Part a
– volume: 11
  start-page: 11
  issue: 1
  year: 2010
  end-page: 18
  article-title: Subcutaneous and visceral adipose tissue: structural and functional differences
  publication-title: Obes Rev
– volume: 22
  start-page: 7644
  issue: 14
  year: 2021
  end-page: 7662
  article-title: Diabetes mellitus and its metabolic complications: the role of adipose tissues
  publication-title: Int J Mol Sci
– volume: 37
  start-page: 115
  issue: 1
  year: 2016
  end-page: 125
  article-title: Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue
  publication-title: Int J Mol Med
– volume: 8
  start-page: 462
  issue: 5
  year: 2019
  end-page: 493
  article-title: Preconditioning in an inflammatory milieu augments the immunotherapeutic function of mesenchymal stromal cells
  publication-title: Cell
– volume: 10
  start-page: 1
  issue: 1
  year: 2019
  end-page: 10
  article-title: Antioxidant‐upregulated mesenchymal stem cells reduce inflammation and improve fatty liver disease in diet‐induced obesity
  publication-title: Stem Cell Res Ther
– volume: 13
  start-page: 1
  issue: SUPPL.2
  year: 2012
  end-page: 5
  article-title: Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview
  publication-title: Obes Rev
– volume: 31
  start-page: e21919‐1
  issue: 8
  year: 2017
  end-page: e21919‐9
  article-title: Significant curative functions of the mesenchymal stem cells on methotrexate‐induced kidney and liver injuries in rats
  publication-title: J Biochem Mol Toxicol
– volume: 11
  start-page: 1054
  issue: 4
  year: 1991
  end-page: 1062
  article-title: Molecular mapping of the mouse ob mutation
  publication-title: Genomics
– volume: 26
  start-page: 1921
  issue: 8
  year: 2018
  end-page: 1930
  article-title: Therapeutic effects of adipose stem cells from diabetic mice for the treatment of type 2 diabetes
  publication-title: Mol Ther
– volume: 37
  start-page: 85
  year: 2017
  end-page: 89
  article-title: Pathology of non‐alcoholic fatty liver disease
  publication-title: Liver Int
– volume: 24
  start-page: 70
  issue: 1
  year: 2009
  end-page: 77
  article-title: Rapid hepatic fate specification of adipose‐derived stem cells and their therapeutic potential for liver failure
  publication-title: J Gastroenterol Hepatol
– volume: 13
  start-page: 1
  issue: 7
  year: 2021
  end-page: 12
  article-title: The emerging role of Sfrp5 and Wnt5a in the pathogenesis of obesity: Implications for a healthy diet and lifestyle
  publication-title: Nutrients
– volume: 9
  start-page: 1
  issue: 12
  year: 2014
  end-page: 15
  article-title: Randomized placebo‐controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis
  publication-title: PLoS ONE
– volume: 6
  start-page: 1
  issue: 1
  year: 2015
  end-page: 13
  article-title: Adipose‐derived mesenchymal stem cells improve glucose homeostasis in high‐fat diet‐induced obese mice
  publication-title: Stem Cell Res Ther
– volume: 24
  start-page: 2292
  issue: 10
  year: 2006
  end-page: 2298
  article-title: Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy
  publication-title: Stem Cells
– volume: 45
  start-page: 344
  issue: 3
  year: 2014
  end-page: 353
  article-title: Non‐alcoholic fatty liver disease: a diabetologist's perspective
  publication-title: Endocrine
– volume: 242
  start-page: 1079
  issue: 10
  year: 2017
  end-page: 1085
  article-title: Diabetic human adipose tissue‐derived mesenchymal stem cells fail to differentiate in functional adipocytes
  publication-title: Exp Biol Med
– volume: 115
  start-page: 1041
  issue: 6
  year: 2019
  end-page: 1051
  article-title: Humoral factors secreted from adipose tissue‐derived mesenchymal stem cells ameliorate atherosclerosis in Ldlr mice
  publication-title: Cardiovasc Res
– volume: 31
  start-page: 487
  issue: 6
  year: 2019
  end-page: 501
  article-title: Autophagy in adipose tissue physiology and pathophysiology
  publication-title: Antioxid Redox Signal
– volume: 58
  start-page: 570
  issue: 4
  year: 2009
  end-page: 581
  article-title: Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
  publication-title: Gut
– volume: 57
  start-page: 167
  issue: 1
  year: 2014
  end-page: 176
  article-title: Characterising metabolically healthy obesity in weight‐discordant monozygotic twins
  publication-title: Diabetologia
– volume: 7
  start-page: 410
  issue: 5
  year: 2008
  end-page: 420
  article-title: Beneficial effects of subcutaneous fat transplantation on metabolism
  publication-title: Cell Metab
– volume: 15
  start-page: 641
  issue: 6
  year: 2013
  end-page: 648
  article-title: Stromal cells from the adipose tissue‐derived stromal vascular fraction and culture expanded adipose tissue‐derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International So
  publication-title: Cytotherapy
– volume: 1
  start-page: 1595
  issue: 1
  year: 2000
  end-page: 1599
  article-title: Plasma concentrations of a novel, adipose‐specific protein, adiponectin, in type 2 diabetic patients
  publication-title: Arter Thrombo Vasc Biol
– volume: 10
  start-page: 709
  issue: 6
  year: 2012
  end-page: 716
  article-title: Mesenchymal stromal cells: new directions
  publication-title: Cell Stem Cell
– volume: 8
  start-page: 315
  issue: 4
  year: 2006
  end-page: 327
  article-title: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
  publication-title: Cytotherapy
– volume: 182
  start-page: 61
  issue: November
  year: 2017
  end-page: 74.e8
  article-title: Mesenchymal stromal cell‐based therapies reduce obesity and metabolic syndromes induced by a high‐fat diet
  publication-title: Transl Res
– volume: 63
  start-page: 783
  issue: 12
  year: 2008
  end-page: 784
  article-title: The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering prevalence and correlates of 2 phenotypes among the US population (NHANES 1999‐2004)
  publication-title: Obstet Gynecol Surv
– volume: 12
  start-page: 1
  issue: June
  year: 2021
  end-page: 7
  article-title: Adipocytes, innate immunity and obesity: a mini‐review
  publication-title: Front Immunol
– volume: 234
  start-page: 218
  issue: 1
  year: 2014
  end-page: 223
  article-title: Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis
  publication-title: Atherosclerosis
– volume: 137
  start-page: 111315
  issue: February
  year: 2021
  end-page: 111328
  article-title: Adipose tissue and insulin resistance in obese
  publication-title: Biomed Pharmacother
– volume: 70
  start-page: 3
  issue: 1
  year: 2012
  end-page: 21
  article-title: Global nutrition transition and the pandemic of obesity in developing countries
  publication-title: Nutr Rev
– volume: 43
  start-page: 2107
  issue: 10
  year: 2019
  end-page: 2118
  article-title: Human adipose tissue mesenchymal stem cells as a novel treatment modality for correcting obesity induced metabolic dysregulation
  publication-title: Int J Obes (Lond)
– volume: 13
  start-page: 1
  issue: 7
  year: 2021
  end-page: 22
  article-title: Metabolic syndrome: is it time to add the central nervous system?
  publication-title: Nutrients
– volume: 40
  start-page: 1279
  issue: 4
  year: 2012
  end-page: 1290
  article-title: Systemic administration of autologous adipose‐derived mesenchymal stem cells alleviates hepatic ischemia‐reperfusion injury in rats
  publication-title: Crit Care Med
– volume: 34
  start-page: 695
  issue: 3
  year: 2014
  end-page: 704
  article-title: Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation
  publication-title: Int J Mol Med
– volume: 15
  start-page: 781
  issue: 10
  year: 2014
  end-page: 790
  article-title: The prevalence of metabolically healthy obesity: a systematic review and critical evaluation of the definitions used
  publication-title: Obes Rev
– volume: 341
  start-page: 1135
  issue: 4
  year: 2006
  end-page: 1140
  article-title: Human adipose tissue‐derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells
  publication-title: Biochem Biophys Res Commun
– volume: 3
  start-page: 89
  issue: 2
  year: 2017
  end-page: 94
  article-title: Association between circulating oxidized low‐density lipoprotein and atherosclerotic cardiovascular disease
  publication-title: Chronic Dis Transl Med
– volume: 85
  start-page: 43
  issue: 1
  year: 2014
  end-page: 77
  article-title: Human adult stem cells from diverse origins: an overview from multiparametric immunophenotyping to clinical applications
  publication-title: Cytom Part A
– volume: 5
  issue: 4
  year: 2010
  article-title: A new mesenchymal stem cell (MSC) paradigm: polarization into a pro‐inflammatory MSC1 or an immunosuppressive MSC2 phenotype
  publication-title: PLoS ONE
– volume: 22
  start-page: 1053
  issue: 6
  year: 2013
  end-page: 1060
  article-title: Differentiation of human adipose tissue‐derived stem cells into aggregates of insulin‐producing cells through the overexpression of pancreatic and duodenal homeobox gene‐1
  publication-title: Cell Transplant
– volume: 29
  start-page: 488
  issue: 8
  year: 2020
  end-page: 497
  article-title: Adipose tissue‐derived stem cell sheet improves glucose metabolism in obese mice
  publication-title: Stem Cells Dev
– volume: 299
  start-page: 506
  issue: 3
  year: 2010
  end-page: 515
  article-title: Insulin‐sensitive obesity
  publication-title: Am J Physiol Endocrinol Metab
– volume: 55
  start-page: 1112
  issue: 5
  year: 2011
  end-page: 1120
  article-title: Intravenous administration of multipotent stromal cells prevents the onset of non‐alcoholic steatohepatitis in obese mice with metabolic syndrome
  publication-title: J Hepatol
– volume: 2017
  start-page: 1
  year: 2017
  end-page: 13
  article-title: Trophic activity and phenotype of adipose tissue‐derived mesenchymal stem cells as a background of their regenerative potential
  publication-title: Stem Cells Int
– volume: 21
  start-page: 1199
  issue: 10
  year: 2009
  end-page: 1205
  article-title: Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I‐II clinical trial
  publication-title: Eur J Gastroenterol Hepatol
– volume: 62
  start-page: 1131
  issue: 8
  year: 2013
  end-page: 1141
  article-title: Adipose‐derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis
  publication-title: Gut
– volume: 20
  start-page: 419
  issue: 5–6
  year: 2009
  end-page: 427
  article-title: Mechanisms involved in the therapeutic properties of mesenchymal stem cells
  publication-title: Cytokine Growth Factor Rev
– year: 2021
  article-title: Comparisons of calorie restriction and structured exercise on reductions in visceral and abdominal subcutaneous adipose tissue: a systematic review
  publication-title: Eur J Clin Nutr
– volume: 1
  start-page: 1
  issue: 1
  year: 2011
  end-page: 10
  article-title: Location, location, location: beneficial effects of autologous fat transplantation
  publication-title: Sci Rep
– volume: 52
  start-page: 855
  issue: 5
  year: 2015
  end-page: 863
  article-title: Lipid accumulation product and visceral adiposity index are effective markers for identifying the metabolically obese normal‐weight phenotype
  publication-title: Acta Diabetol
– volume: 307
  start-page: 380
  issue: 5708
  year: 2005
  end-page: 384
  article-title: Type 2 diabetes—a matter of β‐cell life and death?
  publication-title: Science
– volume: 22
  start-page: 6900
  issue: 13
  year: 2021
  end-page: 6913
  article-title: The role of fatty acids in non‐alcoholic fatty liver disease progression: an update
  publication-title: Int J Mol Sci
– start-page: 101
  year: 2019
  end-page: 116
– start-page: 370
  year: 2018
  end-page: 384
– volume: 16
  start-page: S65
  issue: 7
  year: 2012
  end-page: S69
  article-title: Ex vivo generation of glucose sensitive insulin secreting mesenchymal stem cells derived from human adipose tissue
  publication-title: Indian J Endocrinol Metab
– volume: 443
  start-page: 775
  issue: 2
  year: 2014
  end-page: 781
  article-title: Transplantation of insulin‐secreting cells differentiated from human adipose tissue‐derived stem cells into type 2 diabetes mice
  publication-title: Biochem Biophys Res Commun
– volume: 14
  start-page: 2807
  year: 2021
  end-page: 2827
  article-title: Obesity in patients with type 1 diabetes: links, risks and management challenges
  publication-title: Diabetes, Metab Syndr Obes Targets Ther
– volume: 483
  start-page: 435
  issue: 1
  year: 2017
  end-page: 441
  article-title: Adipose‐derived mesenchymal stem cells ameliorate hyperglycemia through regulating hepatic glucose metabolism in type 2 diabetic rats
  publication-title: Biochem Biophys Res Commun
– volume: 75
  start-page: 4079
  issue: 22
  year: 2018
  end-page: 4091
  article-title: Response of vascular mesenchymal stem/progenitor cells to hyperlipidemia
  publication-title: Cell Mol Life Sci
– volume: 13
  start-page: 466
  issue: 6
  year: 2018
  end-page: 475
  article-title: Adipose‐derived mesenchymal stem cells in the treatment of obesity: a systematic review of longitudinal studies on preclinical evidence
  publication-title: Curr Stem Cell Res Ther
– volume: 6
  start-page: 1
  issue: 1
  year: 2015
  end-page: 10
  article-title: Rapid and high‐efficiency generation of mature functional hepatocyte‐like cells from adipose‐derived stem cells by a three‐step protocol
  publication-title: Stem Cell Res Ther
– volume: 15
  start-page: 504
  issue: 6
  year: 2014
  end-page: 515
  article-title: Metabolically healthy obesity and risk of incident type 2 diabetes: a meta‐analysis of prospective cohort studies
  publication-title: Obes Rev
– volume: 218
  start-page: 25
  issue: 3
  year: 2013
  end-page: 36
  article-title: Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
  publication-title: J Endocrinol
– volume: 126
  start-page: 37
  issue: 1‐2
  year: 2009
  end-page: 42
  article-title: Adipose tissue‐derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow‐derived mesenchymal stem cells
  publication-title: Immunol Lett
– volume: 81
  start-page: 176
  issue: 3
  year: 2011
  end-page: 186
  article-title: Therapeutic potential of adipose tissue‐derived stem cells for liver failure according to the transplantation routes
  publication-title: J Korean Surg Soc
– volume: 1
  start-page: 103
  issue: 3
  year: 2011
  end-page: 106
  article-title: Protective actions of administered mesenchymal stem cells in acute kidney injury: Relevance to clinical trials
  publication-title: Kidney Int Suppl
– volume: 453
  start-page: 783
  issue: 7196
  year: 2008
  end-page: 787
  article-title: Dynamics of fat cell turnover in humans
  publication-title: Nature
– volume: 35
  start-page: 971
  issue: 7
  year: 2011
  end-page: 981
  article-title: Characterizing the profile of obese patients who are metabolically healthy
  publication-title: Int J Obes (Lond)
– volume: 388
  start-page: 1281
  issue: 10051
  year: 2016
  end-page: 1290
  article-title: Expanded allogeneic adipose‐derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double‐blind controlled trial
  publication-title: Lancet
– volume: 15
  start-page: 557
  issue: 5
  year: 2013
  end-page: 570
  article-title: Adipose tissue‐derived mesenchymal stromal cells efficiently differentiate into insulin‐producing cells in pancreatic islet microenvironment both in vitro and in vivo
  publication-title: Cytotherapy
– year: 2021
– volume: 214
  start-page: 62
  issue: August
  year: 2018
  end-page: 69
  article-title: Adipose‐derived stem cells reduce liver oxidative stress and autophagy induced by ischemia‐reperfusion and hepatectomy injury in swine
  publication-title: Life Sci
– volume: 71
  start-page: 466
  year: 2017
  end-page: 484
  article-title: Tkanka tłuszczowa‐charakterystyka morfologiczna i biochemiczna różnych depozytów Adipose tissue‐morphological and biochemical characteristic of different depots
  publication-title: Postepy Hig Med Dosw
– volume: 208
  start-page: 501
  issue: 5
  year: 2015
  end-page: 512
  article-title: The cell biology of fat expansion
  publication-title: J Cell Biol
– volume: 8
  start-page: 1
  issue: 1
  year: 2017
  end-page: 12
  article-title: Adipose tissue‐derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats
  publication-title: Stem Cell Res Ther
– volume: 118
  start-page: 2037
  issue: 8
  year: 2017
  end-page: 2043
  article-title: Conditioned media from adipose tissue derived mesenchymal stem cells reverse insulin resistance in cellular models
  publication-title: J Cell Biochem
– volume: 92
  start-page: 51
  year: 2019
  end-page: 60
  article-title: Metabolically healthy versus metabolically unhealthy obesity
  publication-title: Metabolism
– volume: 2019
  year: 2019
  article-title: Adipose‐derived mesenchymal stem cells promote M2 macrophage phenotype through exosomes
  publication-title: Stem Cells Int
– volume: 27
  start-page: 1941
  issue: 8
  year: 2009
  end-page: 1953
  article-title: Generation of pancreatic hormone‐expressing islet‐like cell aggregates from murine adipose tissue‐derived stem cells
  publication-title: Stem Cells
– volume: 23
  start-page: 149
  issue: 2
  year: 2018
  end-page: 157
  article-title: Insulin resistance in obesity: an overview of fundamental alterations
  publication-title: Eat Weight Disord
– volume: 34
  start-page: 1432
  issue: 8
  year: 2019
  end-page: 1440
  article-title: Adipose tissue‐derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL‐17‐mediated inflammation
  publication-title: J Gastroenterol Hepatol
– volume: 11
  start-page: 812
  issue: 6
  year: 2012
  end-page: 824
  article-title: CCR2‐dependent recruitment of macrophages by tumor‐educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα
  publication-title: Cell Stem Cell
– volume: 456
  start-page: 860
  issue: 4
  year: 2015
  end-page: 865
  article-title: Therapeutic potential of human adipose tissue‐derived multi‐lineage progenitor cells in liver fibrosis
  publication-title: Biochem Biophys Res Commun
– volume: 57
  start-page: 223
  issue: 2
  year: 2008
  end-page: 231
  article-title: Human mesenchymal stem cells as a two‐edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential
  publication-title: Gut
– volume: 15
  start-page: 7352
  issue: 5
  year: 2014
  end-page: 7379
  article-title: Molecular mechanisms and new treatment strategies for non‐alcoholic steatohepatitis (NASH)
  publication-title: Int J Mol Sci
– volume: 10
  start-page: 1
  issue: 1
  year: 2019
  end-page: 13
  article-title: Current understanding of adipose‐derived mesenchymal stem cell‐based therapies in liver diseases
  publication-title: Stem Cell Res Ther
– volume: 292
  start-page: 154
  issue: 5819
  year: 1981
  end-page: 156
  article-title: Establishment in culture of pluripotential cells from mouse embryos
  publication-title: Nature
– volume: 11
  start-page: 6291
  issue: 1
  year: 2021
  end-page: 6302
  article-title: The therapeutic effects of adipose‐derived mesenchymal stem cells on obesity and its associated diseases in diet‐induced obese mice
  publication-title: Sci Rep
– volume: 10
  start-page: 1
  issue: 1
  year: 2019
  end-page: 18
  article-title: Treatment with adipose tissue‐derived mesenchymal stem cells exerts anti‐diabetic effects, improves long‐term complications, and attenuates inflammation in type 2 diabetic rats
  publication-title: Stem Cell Res Ther
– volume: 27
  start-page: 1999
  issue: 8
  year: 2009
  end-page: 2008
  article-title: Insulin‐secreting cells from human eyelid‐derived stem cells alleviate type I diabetes in immunocompetent mice
  publication-title: Stem Cells
– volume: 6
  start-page: 52
  year: 2017
  end-page: 64
  article-title: Phase I clinical study of liver regenerative therapy for cirrhosis by intrahepatic arterial infusion of freshly isolated autologous adipose tissue‐derived stromal/stem (regenerative) cell
  publication-title: Regen Ther
– volume: 24
  start-page: 908
  issue: 7
  year: 2018
  end-page: 922
  article-title: Mechanisms of NAFLD development and therapeutic strategies
  publication-title: Nat Med
– volume: 10
  start-page: 1515
  issue: 6
  year: 2021
  end-page: 1536
  article-title: Does TBC1D4 (AS160) or TBC1D1 deficiency affect the expression of fatty acid handling proteins in the adipocytes differentiated from human adipose‐derived mesenchymal stem cells (ADMSCs) obtained from subcutaneous and visceral fat depots?
  publication-title: Cell
– volume: 33
  start-page: 1257
  issue: 6
  year: 2011
  end-page: 1264
  article-title: A comparison between osteogenic differentiation of human unrestricted somatic stem cells and mesenchymal stem cells from bone marrow and adipose tissue
  publication-title: Biotechnol Lett
– volume: 31
  start-page: 1075
  issue: 5
  year: 2016
  end-page: 1086
  article-title: Transplantation of adipose‐derived stem cells combined with collagen scaffolds restores ovarian function in a rat model of premature ovarian insufficiency
  publication-title: Hum Reprod
– volume: 826
  start-page: 217
  year: 2012
  end-page: 223
  article-title: Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis
  publication-title: Methods Mol Biol
– volume: 11
  start-page: 1
  issue: 7
  year: 2021
  end-page: 13
  article-title: Adipose tissue: understanding the heterogeneity of stem cells for regenerative medicine
  publication-title: Biomolecules
– volume: 229
  start-page: 176
  issue: 2
  year: 2013
  end-page: 185
  article-title: Macrophage plasticity and polarization in tissue repair and remodelling
  publication-title: J Pathol
– volume: 7
  start-page: 211
  issue: 2
  year: 2001
  end-page: 228
  article-title: Multilineage cells from human adipose tissue: Implications for cell‐based therapies
  publication-title: Tissue Eng
– volume: 14
  start-page: 325
  issue: 3
  year: 2006
  end-page: 335
  article-title: Enhanced wound‐healing quality with bone marrow mesenchymal stem cells autografting after skin injury
  publication-title: Wound Repair Regen
– volume: 54
  start-page: 2277
  issue: 24
  year: 2009
  end-page: 2286
  article-title: A randomized, double‐blind, placebo‐controlled, dose‐escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction
  publication-title: J am Coll Cardiol
– volume: 62
  start-page: 339
  issue: 4
  year: 2015
  end-page: 352
  article-title: Effects of autologous adipose‐derived stem cell infusion on type 2 diabetic rats
  publication-title: Endocr J
– volume: 8
  start-page: 1
  issue: 1
  year: 2017
  end-page: 11
  article-title: Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue
  publication-title: Stem Cell Res Ther
– volume: 54
  start-page: 281
  issue: 3
  year: 2005
  end-page: 286
  article-title: Correlation between the adiponectin‐leptin ratio and parameters of insulin resistance in patients with type 2 diabetes
  publication-title: Metabolism
– volume: 109
  start-page: 1292
  issue: 10
  year: 2004
  end-page: 1298
  article-title: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
  publication-title: Circulation
– volume: 282
  start-page: 1145
  issue: 5391
  year: 1998
  end-page: 1147
  article-title: Embryonic stem cell lines derived from human blastocysts
  publication-title: Science (80‐)
– volume: 13
  start-page: 1
  issue: 1
  year: 2015
  end-page: 11
  article-title: Does adipose tissue‐derived stem cell therapy improve graft quality in freshly grafted ovaries?
  publication-title: Reprod Biol Endocrinol
– volume: 54
  start-page: 699
  issue: 4
  year: 2010
  end-page: 705
  article-title: Pdx1‐transfected adipose tissue‐derived stem cells differentiate into insulin‐producing cells in vivo and reduce hyperglycemia in diabetic mice
  publication-title: Int J Dev Biol
– volume: 20
  start-page: 14
  issue: 1
  year: 2012
  end-page: 20
  article-title: Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation
  publication-title: Mol Ther
– volume: 128
  start-page: 951
  issue: 7
  year: 2021
  end-page: 968
  article-title: Obesity, adipose tissue and vascular dysfunction
  publication-title: Circ Res
– volume: 13
  start-page: 1
  issue: 6
  year: 2021
  end-page: 25
  article-title: Visceral adiposity and cancer: role in pathogenesis and prognosis
  publication-title: Nutrients
– volume: 84
  start-page: 1662
  year: 2016
  end-page: 1667
  article-title: Metformin preconditioned adipose derived mesenchymal stem cells is a better option for the reversal of diabetes upon transplantation
  publication-title: Biomed Pharmacother
– volume: 31
  start-page: 445
  issue: 7
  year: 2006
  end-page: 486
  article-title: Pathophysiology, diagnosis, and management of dyslipidemia
  publication-title: Curr Probl Cardiol
– volume: 15
  start-page: 1
  issue: 11 November
  year: 2020
  end-page: 16
  article-title: Association of small, dense LDL‐cholesterol concentration and lipoprotein particle characteristics with coronary heart disease: A systematic review and meta‐analysis
  publication-title: PLoS ONE
– volume: 26
  start-page: 2705
  issue: 10
  year: 2008
  end-page: 2712
  article-title: IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury
  publication-title: Stem Cells
– volume: 12
  start-page: 3725
  issue: 3
  year: 2015
  end-page: 3733
  article-title: Intrahepatic transplantation of adipose‐derived stem cells attenuates the progression of non‐alcoholic fatty liver disease in rats
  publication-title: Mol Med Rep
– volume: 444
  start-page: 860
  issue: 7121
  year: 2006
  end-page: 867
  article-title: Inflammation and metabolic disorders
  publication-title: Nature
– volume: 6
  start-page: e20615‐1
  issue: 6
  year: 2011
  end-page: e20615‐12
  article-title: Islet‐like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice
  publication-title: PLoS ONE
– volume: 294
  start-page: 675
  issue: 3
  year: 2008
  end-page: 682
  article-title: Human mesenchymal stem cells stimulated by TNF‐α, LPS, or hypoxia produce growth factors by an NFκB‐ but not JNK‐dependent mechanism
  publication-title: Am J Physiol Cell Physiol
– volume: 2014
  start-page: 1
  year: 2014
  end-page: 8
  article-title: Cell therapy for chemically induced ovarian failure in mice
  publication-title: Stem Cells Int
– volume: 100
  start-page: 1249
  issue: 9
  year: 2007
  end-page: 1260
  article-title: Adipose‐derived stem cells for regenerative medicine
  publication-title: Circ Res
– volume: 18
  start-page: 1297
  issue: 10
  year: 2016
  end-page: 1311
  article-title: Comparative analysis of the immunomodulatory capacities of human bone marrow‐ and adipose tissue‐derived mesenchymal stromal cells from the same donor
  publication-title: Cytotherapy
– volume: 10
  start-page: 280
  issue: 5
  year: 2019
  end-page: 290
  article-title: Management of diabetic dyslipidemia: an update
  publication-title: World J Diabetes
– volume: 46
  start-page: 3
  issue: 1
  year: 2003
  end-page: 19
  article-title: The relative contributions of insulin resistance and beta‐cell dysfunction to the pathophysiology of type 2 diabetes
  publication-title: Diabetologia
– volume: 2018
  year: 2018
  article-title: Mesenchymal stromal cells support endometriotic stromal cells in vitro
  publication-title: Stem Cells Int
– volume: 14
  start-page: 252
  year: 2020
  end-page: 261
  article-title: Development of a non‐alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles
  publication-title: Regen Ther
– volume: 5
  start-page: e1000324‐1
  issue: 3
  year: 2009
  end-page: e1000324‐11
  article-title: Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth
  publication-title: PLoS Comput Biol
– volume: 244
  start-page: 565
  issue: 7
  year: 2019
  end-page: 578
  article-title: Feature article: transplantation of neuregulin 4‐overexpressing adipose‐derived mesenchymal stem cells ameliorates insulin resistance by attenuating hepatic steatosis
  publication-title: Exp Biol Med
– volume: 20
  start-page: 187
  issue: 1
  year: 2012
  end-page: 195
  article-title: Human MSC suppression correlates with cytokine induction of indoleamine 2,3‐dioxygenase and bystander M2 macrophage differentiation
  publication-title: Mol Ther
– volume: 5
  start-page: 1162
  issue: 9
  year: 2016
  end-page: 1170
  article-title: Adipose‐derived mesenchymal stem cells ameliorate lipid metabolic disturbance in mice
  publication-title: Stem Cells Transl Med
– volume: 16
  start-page: 309
  issue: 3
  year: 2014
  end-page: 318
  article-title: How important is differentiation in the therapeutic effect of mesenchymal stromal cells in liver disease?
  publication-title: Cytotherapy
– volume: 64
  start-page: 926
  issue: 3
  year: 2015
  end-page: 936
  article-title: Niche‐dependent regulations of metabolic balance in high‐fat diet‐induced diabetic mice by mesenchymal stromal cells
  publication-title: Diabetes
– volume: 9
  start-page: 1
  issue: 1
  year: 2019
  end-page: 11
  article-title: Adipose‐derived mesenchymal stromal cells modulate lipid metabolism and lipid droplet biogenesis via AKT/mTOR–PPARγ signalling in macrophages
  publication-title: Sci Rep
– ident: e_1_2_10_71_1
  doi: 10.1161/CIRCRESAHA.121.318093
– ident: e_1_2_10_113_1
  doi: 10.1161/01.CIR.0000121425.42966.F1
– ident: e_1_2_10_22_1
  doi: 10.1038/s41366-019-0438-5
– ident: e_1_2_10_23_1
  doi: 10.1186/s13287-019-1310-1
– ident: e_1_2_10_114_1
  doi: 10.1007/s00018-018-2859-z
– ident: e_1_2_10_53_1
  doi: 10.1038/kisup.2011.24
– ident: e_1_2_10_63_1
  doi: 10.3892/ijmm.2015.2413
– ident: e_1_2_10_98_1
  doi: 10.1161/01.ATV.20.6.1595
– ident: e_1_2_10_29_1
  doi: 10.5604/01.3001.0010.3829
– ident: e_1_2_10_20_1
  doi: 10.1016/j.atherosclerosis.2014.02.033
– volume: 6
  start-page: 1
  year: 2016
  ident: e_1_2_10_67_1
  article-title: Adipose stem cells display higher regenerative capacities and more adaptable electro‐kinetic properties compared to bone marrow‐derived mesenchymal stromal cells
  publication-title: Sci Rep
  doi: 10.1038/srep37801
– ident: e_1_2_10_96_1
  doi: 10.1126/science.1104345
– ident: e_1_2_10_124_1
  doi: 10.1155/2019/7921760
– ident: e_1_2_10_12_1
  doi: 10.1038/ijo.2010.235
– ident: e_1_2_10_108_1
  doi: 10.1016/j.cdtm.2017.02.008
– ident: e_1_2_10_116_1
  doi: 10.1136/gutjnl-2012-302152
– ident: e_1_2_10_31_1
  doi: 10.1111/j.1467-789X.2012.01032.x
– ident: e_1_2_10_10_1
  doi: 10.1152/ajpendo.00586.2009
– ident: e_1_2_10_66_1
  doi: 10.1634/stemcells.2008-0034
– ident: e_1_2_10_152_1
  doi: 10.1016/j.reth.2016.12.001
– ident: e_1_2_10_54_1
  doi: 10.1111/j.1743-6109.2006.00128.x
– volume: 12
  start-page: 1
  year: 2021
  ident: e_1_2_10_5_1
  article-title: Adipocytes, innate immunity and obesity: a mini‐review
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.650768
– ident: e_1_2_10_6_1
  doi: 10.3390/nu13072459
– ident: e_1_2_10_134_1
  doi: 10.1016/j.bbrc.2014.11.122
– ident: e_1_2_10_4_1
– ident: e_1_2_10_129_1
  doi: 10.1186/s13287-017-0743-7
– ident: e_1_2_10_142_1
  doi: 10.1136/gut.2006.111617
– ident: e_1_2_10_146_1
  doi: 10.1097/CCM.0b013e31823dae23
– ident: e_1_2_10_72_1
  doi: 10.1177/1535370219839643
– ident: e_1_2_10_91_1
  doi: 10.1371/journal.pone.0020615
– ident: e_1_2_10_64_1
  doi: 10.1016/j.jcyt.2016.07.006
– ident: e_1_2_10_78_1
  doi: 10.2337/db14-1042
– ident: e_1_2_10_130_1
  doi: 10.3390/cells8050462
– ident: e_1_2_10_41_1
  doi: 10.1038/292154a0
– ident: e_1_2_10_81_1
  doi: 10.1186/s13287-019-1474-8
– ident: e_1_2_10_65_1
  doi: 10.1155/2017/1653254
– volume: 15
  start-page: 1
  issue: 11
  year: 2020
  ident: e_1_2_10_107_1
  article-title: Association of small, dense LDL‐cholesterol concentration and lipoprotein particle characteristics with coronary heart disease: A systematic review and meta‐analysis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0241993
– ident: e_1_2_10_115_1
  doi: 10.1093/cvr/cvy271
– ident: e_1_2_10_135_1
  doi: 10.1007/s12020-013-0087-8
– ident: e_1_2_10_61_1
  doi: 10.1089/ten.tea.2014.0115
– ident: e_1_2_10_83_1
  doi: 10.1016/j.bbrc.2016.12.125
– ident: e_1_2_10_150_1
  doi: 10.1530/JOE-13-0201
– volume: 4
  start-page: 1001
  issue: 5
  year: 2008
  ident: e_1_2_10_106_1
  article-title: Targeting multiple dyslipidemias with fixed combinations—focus on extended release niacin and simvastatin
  publication-title: Vasc Health Risk Manag
– ident: e_1_2_10_18_1
  doi: 10.1111/obr.12157
– ident: e_1_2_10_69_1
  doi: 10.1038/nature06902
– ident: e_1_2_10_93_1
  doi: 10.4103/2230-8210.94264
– ident: e_1_2_10_109_1
  doi: 10.4239/wjd.v10.i5.280
– ident: e_1_2_10_37_1
  doi: 10.1016/j.biopha.2021.111315
– ident: e_1_2_10_74_1
  doi: 10.1016/j.reth.2020.03.012
– ident: e_1_2_10_90_1
  doi: 10.1387/ijdb.092953hk
– ident: e_1_2_10_51_1
  doi: 10.1634/stemcells.2005-0542
– ident: e_1_2_10_36_1
  doi: 10.1007/s40519-018-0481-6
– ident: e_1_2_10_101_1
  doi: 10.1016/j.bbrc.2013.10.059
– ident: e_1_2_10_84_1
  doi: 10.1111/jgh.14647
– ident: e_1_2_10_89_1
  doi: 10.1002/stem.117
– ident: e_1_2_10_86_1
  doi: 10.1016/j.ejphar.2020.173215
– ident: e_1_2_10_151_1
  doi: 10.3390/ijms15057352
– ident: e_1_2_10_121_1
  doi: 10.1016/j.stem.2012.08.013
– ident: e_1_2_10_147_1
  doi: 10.1016/j.jhep.2011.02.020
– ident: e_1_2_10_68_1
  doi: 10.1016/j.jcyt.2013.01.005
– ident: e_1_2_10_97_1
  doi: 10.1016/j.metabol.2004.09.006
– ident: e_1_2_10_9_1
– ident: e_1_2_10_117_1
  doi: 10.1038/s41598-019-56835-8
– ident: e_1_2_10_45_1
  doi: 10.1080/14653240600855905
– ident: e_1_2_10_92_1
  doi: 10.3727/096368912X657215
– ident: e_1_2_10_49_1
  doi: 10.1016/j.jacc.2009.06.055
– ident: e_1_2_10_103_1
  doi: 10.1155/2014/720753
– ident: e_1_2_10_15_1
  doi: 10.1007/s00125-013-3066-y
– ident: e_1_2_10_39_1
  doi: 10.1016/j.cmet.2008.04.004
– ident: e_1_2_10_123_1
  doi: 10.1002/path.4133
– ident: e_1_2_10_17_1
  doi: 10.1016/j.metabol.2018.11.009
– ident: e_1_2_10_77_1
  doi: 10.1186/s13287-015-0201-3
– ident: e_1_2_10_148_1
  doi: 10.1002/hep.26470
– ident: e_1_2_10_48_1
  doi: 10.1371/journal.pone.0113936
– ident: e_1_2_10_21_1
  doi: 10.1038/s41598-021-85917-9
– ident: e_1_2_10_44_1
  doi: 10.1002/cyto.a.22402
– ident: e_1_2_10_38_1
  doi: 10.1111/j.1467-789X.2009.00623.x
– ident: e_1_2_10_105_1
  doi: 10.1093/humrep/dew041
– start-page: 370
  volume-title: Encyclopedia of Endocrine Diseases
  year: 2018
  ident: e_1_2_10_30_1
– ident: e_1_2_10_57_1
  doi: 10.1016/j.jcyt.2013.02.006
– ident: e_1_2_10_16_1
  doi: 10.1111/obr.12198
– ident: e_1_2_10_145_1
  doi: 10.1016/j.lfs.2018.10.054
– ident: e_1_2_10_55_1
  doi: 10.1089/107632701300062859
– ident: e_1_2_10_46_1
  doi: 10.3892/mmr.2015.3847
– ident: e_1_2_10_70_1
  doi: 10.1186/1471-2164-14-625
– ident: e_1_2_10_141_1
  doi: 10.1016/j.jcyt.2013.07.011
– ident: e_1_2_10_35_1
  doi: 10.1177/1535370216681552
– ident: e_1_2_10_87_1
  doi: 10.1016/j.bbrc.2006.01.072
– ident: e_1_2_10_7_1
  doi: 10.3390/nu13062101
– ident: e_1_2_10_32_1
  doi: 10.3390/ijms22147644
– ident: e_1_2_10_126_1
  doi: 10.1152/ajpregu.00280.2006
– ident: e_1_2_10_14_1
  doi: 10.1097/01.ogx.0000338100.83483.58
– ident: e_1_2_10_125_1
  doi: 10.1016/j.imlet.2009.07.010
– ident: e_1_2_10_138_1
  doi: 10.1097/SLA.0000000000001155
– ident: e_1_2_10_88_1
  doi: 10.1002/stem.127
– ident: e_1_2_10_122_1
  doi: 10.1371/journal.pone.0010088
– ident: e_1_2_10_75_1
  doi: 10.1016/j.trsl.2016.11.003
– ident: e_1_2_10_132_1
  doi: 10.1111/liv.13301
– ident: e_1_2_10_143_1
  doi: 10.1007/978-1-61779-468-1_17
– ident: e_1_2_10_19_1
  doi: 10.1007/s00592-015-0715-2
– ident: e_1_2_10_104_1
  doi: 10.1155/2018/7318513
– ident: e_1_2_10_120_1
  doi: 10.1038/mt.2011.211
– ident: e_1_2_10_112_1
  doi: 10.1152/ajpheart.01071.2003
– ident: e_1_2_10_59_1
  doi: 10.1007/s10529-011-0541-8
– ident: e_1_2_10_60_1
  doi: 10.1186/s13287-017-0716-x
– ident: e_1_2_10_13_1
  doi: 10.1038/ijo.2010.216
– ident: e_1_2_10_62_1
  doi: 10.3892/ijmm.2014.1821
– ident: e_1_2_10_79_1
  doi: 10.1016/j.biopha.2016.10.086
– ident: e_1_2_10_73_1
  doi: 10.1186/s13287-019-1393-8
– ident: e_1_2_10_25_1
  doi: 10.1016/0888-7543(91)90032-A
– ident: e_1_2_10_99_1
  doi: 10.1083/jcb.201409063
– ident: e_1_2_10_56_1
  doi: 10.3390/biom11070918
– ident: e_1_2_10_52_1
  doi: 10.1016/S0140-6736(16)31203-X
– ident: e_1_2_10_27_1
  doi: 10.1371/journal.pcbi.1000324
– ident: e_1_2_10_95_1
  doi: 10.1007/s00125-002-1009-0
– ident: e_1_2_10_94_1
  doi: 10.3390/cells10061515
– ident: e_1_2_10_47_1
  doi: 10.1002/stem.430
– ident: e_1_2_10_118_1
  doi: 10.1038/nature05485
– ident: e_1_2_10_137_1
  doi: 10.1136/gut.2008.154880
– ident: e_1_2_10_133_1
  doi: 10.3390/ijms22136900
– volume: 7
  start-page: 1
  year: 2016
  ident: e_1_2_10_34_1
  article-title: Adipose tissue remodeling: its role in energy metabolism and metabolic disorders
  publication-title: Front Endocrinol (Lausanne)
– ident: e_1_2_10_82_1
  doi: 10.1016/j.ymthe.2018.06.013
– ident: e_1_2_10_2_1
  doi: 10.1111/j.1753-4887.2011.00456.x
– ident: e_1_2_10_131_1
  doi: 10.1038/mt.2011.189
– ident: e_1_2_10_76_1
  doi: 10.5966/sctm.2015-0239
– ident: e_1_2_10_26_1
  doi: 10.1385/ENDO:29:1:81
– ident: e_1_2_10_136_1
  doi: 10.1038/s41591-018-0104-9
– ident: e_1_2_10_119_1
  doi: 10.1016/j.stem.2012.05.015
– ident: e_1_2_10_127_1
  doi: 10.1152/ajpcell.00437.2007
– ident: e_1_2_10_110_1
  doi: 10.1016/j.cpcardiol.2006.03.001
– start-page: 101
  volume-title: Biointegration of Medical Implant Materials
  year: 2019
  ident: e_1_2_10_43_1
– ident: e_1_2_10_11_1
  doi: 10.1053/meta.2001.27213
– ident: e_1_2_10_50_1
  doi: 10.1097/MEG.0b013e32832a1f6c
– ident: e_1_2_10_28_1
  doi: 10.1089/ars.2018.7626
– ident: e_1_2_10_139_1
  doi: 10.1111/j.1440-1746.2008.05496.x
– ident: e_1_2_10_33_1
  doi: 10.1038/s41430-021-00942-1
– ident: e_1_2_10_42_1
  doi: 10.1126/science.282.5391.1145
– ident: e_1_2_10_85_1
  doi: 10.1507/endocrj.EJ14-0584
– ident: e_1_2_10_149_1
  doi: 10.4174/jkss.2011.81.3.176
– ident: e_1_2_10_40_1
  doi: 10.1038/srep00081
– ident: e_1_2_10_58_1
  doi: 10.1161/01.RES.0000265074.83288.09
– ident: e_1_2_10_128_1
  doi: 10.1016/j.cytogfr.2009.10.002
– ident: e_1_2_10_102_1
  doi: 10.1186/s12958-015-0104-2
– ident: e_1_2_10_100_1
  doi: 10.1002/jcb.25777
– ident: e_1_2_10_140_1
  doi: 10.1186/s13287-015-0181-3
– ident: e_1_2_10_3_1
  doi: 10.2147/DMSO.S223618
– ident: e_1_2_10_24_1
  doi: 10.2174/1574888X13666180515160008
– ident: e_1_2_10_80_1
  doi: 10.1089/scd.2019.0250
– ident: e_1_2_10_144_1
  doi: 10.1002/jbt.21919
– ident: e_1_2_10_8_1
  doi: 10.3390/nu13072254
– ident: e_1_2_10_111_1
  doi: 10.1161/ATVBAHA.109.187179
SSID ssj0017931
Score 2.4994702
SecondaryResourceType review_article
Snippet Summary Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell‐based therapies have...
Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell‐based therapies have become...
Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell-based therapies have become...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e13413
SubjectTerms adipose tissue
Adipose Tissue - metabolism
ADMSCs
Animal models
Animals
Autografts
Cell viability
Chemokines
Cirrhosis
Clinical trials
Cytokines
Cytokines - metabolism
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Dyslipidemia
Graft rejection
Growth factors
Humans
Hyperglycemia
hyperlipidemia
Immunomodulation
immunosuppression
Inflammation
Insulin
insulin resistance
islets of Langerhans
Liver
Liver cirrhosis
liver function
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Metabolic Diseases - metabolism
Metabolic disorders
Metabolic syndrome
Metabolism
noninsulin-dependent diabetes mellitus
Obesity
Obesity - complications
Obesity - metabolism
Obesity - therapy
Obesity Comorbidities/Treatment
Oxidative stress
Recovery of function
Risk analysis
Risk factors
Stem cell transplantation
Stem cells
therapeutics
Transplantation
Title Using adipose‐derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fobr.13413
https://www.ncbi.nlm.nih.gov/pubmed/34985174
https://www.proquest.com/docview/2648954900
https://www.proquest.com/docview/2616960422
https://www.proquest.com/docview/2661055676
https://pubmed.ncbi.nlm.nih.gov/PMC9285813
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxRBEC5iDuLFt2ZiDK14yGWWmd7p7p14CCqGIEQlGMhBGPo1ZDGZCbuzEXPyJ_gb_SWp6nmQNSribaCroR9V01VdX38F8EIINU6dzmKTaAxQOJ_EOtF5LBNKP8pE80CZv_9e7h1m747E0Qq87N_CtPwQw4UbWUb4X5OBazO_YuS1mY2IjYyYPgmrRQ7RwUAdRXqXti-LFCHm0o5ViFA8Q8_ls-iag3kdJ3nVfw0H0O4d-NwPvcWdfBktGjOyF7-wOv7n3O7C7c4xZa9aTboHK766Dzf3u9T7A5gFcAHTbnpWz_3P7z8c6u65d-yU3i_Z42-n2JtYoRnlAuasqVlJgT9DDxNlGlS2k6llSxB2VpesbisTbDM8FmaeuZp99SxccOw8hMPdt5_e7MVdwYbYCnTLcL_HpSoxYhOW52kpnCxVap0njj10Iw3ug3cqsYJndmyk9lbmqRGpwyMxFzYdP4LVqq78GjCtc-e0ElQ8K8szlPDKJEb7MpclhogRbPVbV9iOzZyKapwUfVSDa1iENYzg-SB61lJ4_E5oo9__orPieUHoP0qDJkkEz4ZmtD9aSF35ekEyqSSCG87_JiNDHVIlI3jcqtQwEpzdhNjCI1BLyjYIEP_3cks1PQ484DmfiAkNfSvo0p8nV3x4fRA-1v9d9Anc4vTSI2A7N2C1mS38U_S_GrMJN3j2cTOY2yVvBS5J
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEB9qBfXF749o1VV86EuOZJPdvYggKpZTexVKC32RsNnd0MM2KXc5RZ_8E_wb_Uuc2XzQsyriW2BnYT9mMjM7M78BeCKESmKr07CINDoonI9DHekslBGFH2WkuYfMn-7IyX769kAcrMGzvhamxYcYHtxIMvz_mgScHqRPSXldzEcER5acg_PU0ds7VLsDeBRxXtzWFinKmYs7XCHK4xmmrmqjMybm2UzJ0xasV0FbV-BDv_g28-TjaNkUI_P1F1zH_93dVbjc2absRctM12DNVdfhwrSLvt-Auc8vYNrOTuqF-_Htu0X2_eQsO6YSJnP45RhnEzA0o3DAgjU1K8n3Z2hkIk2D_HY0M2wli53VJavb5gRPGWqGuWO2Zp8d828cz2_C_tbrvVeTsOvZEBqBlhleeVKqEp02YXgWl8LKUsXGOoLZQ0uywItwVkVG8NQkhdTOyCwuRGxRK2bCxMktWK_qyt0BpnVmrVaC-melWYoUThVRoV2ZyRK9xAA2-7vLTQdoTn01jvLescEzzP0ZBvB4ID1pUTx-R7TRM0DeCfIipwRAioRGUQCPhmEUQTpIXbl6STSxJIwbzv9GI30rUiUDuN3y1LAS3N2YAMMDUCvcNhAQBPjqSDU79FDgGR-LMS190zPTnzeXv3-56z_u_jvpQ7g42Ztu59tvdt7dg0ucCj98qucGrDfzpbuP5lhTPPBS9xMI3jGN
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIlVcKG9SChjEoZes4iR2EjggoKzKowVVVOqhUuTYjrqiTVa7WRCc-An8Rn4JM85DXQoIcYvksWR7ZuIZz8w3AI-ESCJuVOwXgUIHJQxTXwUq82VA4UcZqNBB5u_uyZ2D-PWhOFyBJ30tTIsPMTy4kWa4_zUp-NSUZ5S8LmYjQiOLLsDFWAYpifT2_oAdRYLH29KihFLmeAcrRGk8w9Tly-ichXk-UfKsAetuoPE6HPVrbxNPPo4WTTHSX3-BdfzPzV2By51lyp61onQVVmx1DdZ2u9j7dZi57AKmzGRaz-2Pb98NCu8na9gpFTDp4y-nOJtgoRkFA-asqVlJnj9DExNpGpS2k4lmSznsrC5Z3bYmeMzwXphZZmr22TL3wvH0BhyMX354seN3HRt8LdAuQ4ZHZVKiyyZ0mPFSGFkmXBtLIHtoRxbIB2uSQIsw1lEhldUy44XgBu_ETGge3YTVqq7sbWBKZcaoRFD3rDiLkcImRVAoW2ayRB_Rg62edbnu4Mypq8ZJ3rs1eIa5O0MPHg6k0xbD43dEmz3_806N5zml_1EcNAg8eDAMowLSQarK1gui4ZIQbsLwbzTSNSJNpAe3WpEaVoK7Swku3INkSdgGAgIAXx6pJscOCDwLU5HS0recLP15c_m75_vuY-PfSe_D2vvtcf721d6bO3AppKoPl-e5CavNbGHvoi3WFPeczv0Ed_IwRQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Using+adipose%E2%80%90derived+mesenchymal+stem+cells+to+fight+the+metabolic+complications+of+obesity%3A+Where+do+we+stand%3F&rft.jtitle=Obesity+reviews&rft.au=Mik%C5%82osz%2C+Agnieszka&rft.au=Nikitiuk%2C+Barbara+Emilia&rft.au=Chabowski%2C+Adrian&rft.date=2022-05-01&rft.issn=1467-7881&rft.eissn=1467-789X&rft.volume=23&rft.issue=5&rft.epage=n%2Fa&rft_id=info:doi/10.1111%2Fobr.13413&rft.externalDBID=10.1111%252Fobr.13413&rft.externalDocID=OBR13413
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1467-7881&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1467-7881&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1467-7881&client=summon