Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors

• Published in: Nature communications Vol. 9; no. 1; pp. 1 - 17
• Main Authors: Luo, Yan-Jia, Li, Ya-Dong, Wang, Lu, Yang, Su-Rong, Yuan, Xiang-Shan, Wang, Juan, Cherasse, Yoan, Lazarus, Michael, Chen, Jiang-Fan, Qu, Wei-Min, Huang, Zhi-Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.04.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/51; 14/19; 14/28; 14/34; 14/63; 38/88; 631/378/1385/1877; 631/378/3920; 64/110; 9/26; 9/74; Animal behavior; Arousal; Dopamine; Dopamine D1 receptors; Electron microscopy; Eye movements; Food intake; Humanities and Social Sciences; Hypothalamus; Hypothalamus (lateral); Immunohistochemistry; Mesencephalon; multidisciplinary; Neurons; NREM sleep; Nuclei; Nucleus accumbens; Orexins; Photoactivation; Photometry; Receptors; REM sleep; Rodents; Science; Science (multidisciplinary); Sleep; Sleep and wakefulness; Wakefulness

Nucleus accumbens (NAc) is involved in behaviors that depend on heightened wakefulness, but its impact on arousal remains unclear. Here, we demonstrate that NAc dopamine D 1 receptor (D 1 R)-expressing neurons are essential for behavioral arousal. Using in vivo fiber photometry in mice, we find arou...