Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma

• Published in: Allergy (Copenhagen) Vol. 67; no. 12; pp. 1601 - 1604
• Main Authors: Bains, S. N., Tourkina, E., Atkinson, C., Joseph, K., Tholanikunnel, B., Chu, H. W., Riemer, E. C., Martin, R., Hoffman, S.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.12.2012; Blackwell
• Subjects: allergen; Animal models; Animals; Aspergillus fumigatus; Asthma; Asthma - metabolism; Biological and medical sciences; Biopsy; Bronchi - metabolism; Caveolin 1 - deficiency; Caveolin 1 - metabolism; caveolin-1; Cellular biology; Chronic obstructive pulmonary disease, asthma; Collagen (type I); Dermatology; Disease Models, Animal; Epithelial cells; Epithelial Cells - metabolism; epithelium; Extracellular matrix; Extracellular Matrix Proteins - metabolism; Female; Fibrosis; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene expression; Humans; Immunohistochemistry; Inflammation; Lung; Lung - metabolism; Lung - pathology; Medical sciences; Mice; Monocytes; Monocytes - metabolism; Peripheral blood; Pneumology; Proteins; regulatory proteins; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Signal Transduction; Tenascin; Human; Lung disease; Allergy; Immunopathology; Monocyte; Respiratory disease; Dermatology; Bronchus; Epithelium; Respiratory system; Asthma; Respiratory tract; Caveolin 1; Immunology; Bronchus disease; Epithelial cell; Obstructive pulmonary disease; Allergen

Background Caveolin‐1 has emerged as a critical regulator of signaling pathways involved in lung fibrosis and inflammation. Methods Therefore, we investigated whether caveolin‐1 is deficient in asthmatic patients and in a murine model of asthma. Results Immunohistochemical analyses of endobronchial...