Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment

• Published in: Journal of cellular and molecular medicine Vol. 23; no. 4; pp. 2324 - 2332
• Main Authors: Fang, Hong, Tu, Sheng, Sheng, Jifang, Shao, Anwen
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2019; John Wiley and Sons Inc
• Subjects: Antidepressants; Antidepressive Agents - therapeutic use; bidirectional relation; Bipolar disorder; Circadian rhythm; depression; Depression - complications; Depression - drug therapy; Depression - physiopathology; Depressive Disorder, Major - complications; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - physiopathology; Humans; Hypnotics; Hypnotics and Sedatives - therapeutic use; mechanism; Mental depression; Mental disorders; Review; Reviews; Risk Factors; Sleep; Sleep disorders; sleep disturbance; Sleep Initiation and Maintenance Disorders - complications; Sleep Initiation and Maintenance Disorders - drug therapy; Sleep Initiation and Maintenance Disorders - physiopathology; Sleep Wake Disorders - complications; Sleep Wake Disorders - drug therapy; Sleep Wake Disorders - physiopathology; treatment; treatment; bidirectional relation; depression; sleep disturbance; mechanism

Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among yo...