Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment

Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among yo...

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Published inJournal of cellular and molecular medicine Vol. 23; no. 4; pp. 2324 - 2332
Main Authors Fang, Hong, Tu, Sheng, Sheng, Jifang, Shao, Anwen
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.04.2019
John Wiley and Sons Inc
Subjects
Antidepressants
Antidepressive Agents - therapeutic use
bidirectional relation
Bipolar disorder
Circadian rhythm
depression
Depression - complications
Depression - drug therapy
Depression - physiopathology
Depressive Disorder, Major - complications
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - physiopathology
Humans
Hypnotics
Hypnotics and Sedatives - therapeutic use
mechanism
Mental depression
Mental disorders
Review
Reviews
Risk Factors
Sleep
Sleep disorders
sleep disturbance
Sleep Initiation and Maintenance Disorders - complications
Sleep Initiation and Maintenance Disorders - drug therapy
Sleep Initiation and Maintenance Disorders - physiopathology
Sleep Wake Disorders - complications
Sleep Wake Disorders - drug therapy
Sleep Wake Disorders - physiopathology
treatment
treatment
bidirectional relation
depression
sleep disturbance
mechanism
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Abstract Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle‐aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non‐pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity.
AbstractList Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle-aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non-pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity.Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle-aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non-pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity.
Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle‐aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non‐pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity.
Author Fang, Hong
Sheng, Jifang
Tu, Sheng
Shao, Anwen
AuthorAffiliation 1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou City, Zhejiang Province China
2 Department of Neurosurgery Second Affiliated Hospital School of Medicine, Zhejiang University Hangzhou City, Zhejiang Province China
AuthorAffiliation_xml – name: 1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou City, Zhejiang Province China
– name: 2 Department of Neurosurgery Second Affiliated Hospital School of Medicine, Zhejiang University Hangzhou City, Zhejiang Province China
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  givenname: Hong
  surname: Fang
  fullname: Fang, Hong
  organization: Zhejiang University
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  givenname: Sheng
  surname: Tu
  fullname: Tu, Sheng
  organization: Zhejiang University
– sequence: 3
  givenname: Jifang
  surname: Sheng
  fullname: Sheng, Jifang
  email: jifang_sheng@zju.edu.cn
  organization: Zhejiang University
– sequence: 4
  givenname: Anwen
  orcidid: 0000-0001-5616-0394
  surname: Shao
  fullname: Shao, Anwen
  email: 21118116@zju.edu.cn, anwenshao@sina.com
  organization: Second Affiliated Hospital School of Medicine, Zhejiang University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30734486$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords treatment
bidirectional relation
depression
sleep disturbance
mechanism
Language English
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Hong Fang and Sheng Tu contribute equally to the manuscript.
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Snippet Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many...
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StartPage 2324
SubjectTerms Antidepressants
Antidepressive Agents - therapeutic use
bidirectional relation
Bipolar disorder
Circadian rhythm
depression
Depression - complications
Depression - drug therapy
Depression - physiopathology
Depressive Disorder, Major - complications
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - physiopathology
Humans
Hypnotics
Hypnotics and Sedatives - therapeutic use
mechanism
Mental depression
Mental disorders
Review
Reviews
Risk Factors
Sleep
Sleep disorders
sleep disturbance
Sleep Initiation and Maintenance Disorders - complications
Sleep Initiation and Maintenance Disorders - drug therapy
Sleep Initiation and Maintenance Disorders - physiopathology
Sleep Wake Disorders - complications
Sleep Wake Disorders - drug therapy
Sleep Wake Disorders - physiopathology
treatment
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Title Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcmm.14170
https://www.ncbi.nlm.nih.gov/pubmed/30734486
https://www.proquest.com/docview/2197019195
https://www.proquest.com/docview/2459096331
https://www.proquest.com/docview/2197888718
https://pubmed.ncbi.nlm.nih.gov/PMC6433686
Volume 23
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