Cobalt-Catalyzed Oxidative C−H/C−H Cross-Coupling between Two Heteroarenes

• Published in: Angewandte Chemie International Edition Vol. 55; no. 35; pp. 10414 - 10418
• Main Authors: Tan, Guangying, He, Shuang, Huang, Xiaolei, Liao, Xingrong, Cheng, Yangyang, You, Jingsong
• Format: Journal Article
• Language: English
• Published: WEINHEIM Blackwell Publishing Ltd 22.08.2016; Wiley; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Activation; bi(hetero)aryls; Chemical reactions; Chemistry; Chemistry, Multidisciplinary; Cobalt; cobalt catalysis; Coupling; Cross coupling; Deuterium; Electron paramagnetic resonance; Electron transfer; Exchanging; Functional anatomy; Functional groups; High resolution; High temperature; Hydrogen; Isotope effect; Mass spectrometry; Mass spectroscopy; oxidative C−H/C−H cross-coupling; Oxidizing agents; Physical Sciences; Reaction time; Science & Technology; SET pathway; Temperature effects; Trapping; DIRECT ARYLATION; bi(hetero) aryls; DIRECTED C(SP)-H; oxidative C-H/C-H cross-coupling; UNACTIVATED ARENES; INDOLES; BIDENTATE-CHELATION ASSISTANCE; ALIPHATIC AMIDES; FUNCTIONALIZATION; SET pathway; ARYL HALIDES; BOND ACTIVATION; cobalt catalysis; AMINOQUINOLINE BENZAMIDES; bi(hetero)aryls; oxidative C−H/C−H cross-coupling

The first example of cobalt‐catalyzed oxidative C−H/C−H cross‐coupling between two heteroarenes is reported, which exhibits a broad substrate scope and a high tolerance level for sensitive functional groups. When the amount of Co(OAc)2⋅4 H2O is reduced from 6.0 to 0.5 mol %, an excellent yield is st...