Enzymatic Regioselection for the Synthesis and Biodegradation of Porphysome Nanovesicles
A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin–lipid regioisomers (see picture). Either of the isomerically pure conjugates assembles into physically similar porphysome nanovesicles. Although porphysomes formed from both regioisomers are stable in se...
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| Published in | Angewandte Chemie International Edition Vol. 51; no. 10; pp. 2429 - 2433 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Weinheim
WILEY-VCH Verlag
05.03.2012
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
| Edition | International ed. in English |
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| Abstract | A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin–lipid regioisomers (see picture). Either of the isomerically pure conjugates assembles into physically similar porphysome nanovesicles. Although porphysomes formed from both regioisomers are stable in serum in vivo, only one regioisomer rapidly degrades upon uptake in the liver. |
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| AbstractList | A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin-lipid regioisomers (see picture). Either of the isomerically pure conjugates assembles into physically similar porphysome nanovesicles. Although porphysomes formed from both regioisomers are stable in serum invivo, only one regioisomer rapidly degrades upon uptake in the liver. A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin–lipid regioisomers (see picture). Either of the isomerically pure conjugates assembles into physically similar porphysome nanovesicles. Although porphysomes formed from both regioisomers are stable in serum in vivo, only one regioisomer rapidly degrades upon uptake in the liver. |
| Author | MacDonald, Thomas D. Jin, Cheng S. Huynh, Elizabeth Lovell, Jonathan F. Zheng, Gang Cao, Weiguo |
| Author_xml | – sequence: 1 givenname: Jonathan F. surname: Lovell fullname: Lovell, Jonathan F. organization: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5G1L7 (Canada) http://www.utoronto.ca/zhenglab – sequence: 2 givenname: Cheng S. surname: Jin fullname: Jin, Cheng S. organization: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5G1L7 (Canada) http://www.utoronto.ca/zhenglab – sequence: 3 givenname: Elizabeth surname: Huynh fullname: Huynh, Elizabeth organization: Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G1L7 (Canada) – sequence: 4 givenname: Thomas D. surname: MacDonald fullname: MacDonald, Thomas D. organization: Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, M5G1L7 (Canada) – sequence: 5 givenname: Weiguo surname: Cao fullname: Cao, Weiguo organization: Ontario Cancer Institute, the Campbell Family Institute for Cancer Research, and Techna Institute, University Health Network, Toronto, ON, M5G1L7 (Canada) – sequence: 6 givenname: Gang surname: Zheng fullname: Zheng, Gang email: gzheng@uhnres.utoronto.ca organization: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5G1L7 (Canada) http://www.utoronto.ca/zhenglab |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22267090$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| Snippet | A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin–lipid regioisomers (see picture). Either of the isomerically... A select few: An enzyme screen is used to identify two enzymes that selectively cleave porphyrin-lipid regioisomers (see picture). Either of the isomerically... |
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| SubjectTerms | Animals Biodegradation Chromatography, High Pressure Liquid Conjugates Enzymes Enzymes - chemistry Isomerism Liver Magnetic Resonance Spectroscopy Mice Microscopy, Electron, Transmission nanoparticles Nanoparticles - chemistry Nanostructure phospholipids Phospholipids - chemistry Phospholipids - metabolism porphyrinoids Porphyrins - chemistry Porphyrins - metabolism regioselectivity Screens Serums Stereoisomerism Synthesis Uptakes |
| Title | Enzymatic Regioselection for the Synthesis and Biodegradation of Porphysome Nanovesicles |
| URI | https://api.istex.fr/ark:/67375/WNG-M1ZM7B1P-6/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.201108280 https://www.ncbi.nlm.nih.gov/pubmed/22267090 https://www.proquest.com/docview/1516660623 https://www.proquest.com/docview/1544012755 https://www.proquest.com/docview/1701110221 https://www.proquest.com/docview/926155738 |
| Volume | 51 |
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