Genetically Targeted Clinical Trials in Parkinson's Disease: Learning from the Successes Made in Oncology

Clinical trials in neurodegenerative disorders have been associated with high rate of failures, while in oncology, the implementation of precision medicine and focus on genetically defined subtypes of disease and targets for drug development have seen an unprecedented success. With more than 20 gene...

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Published inGenes Vol. 12; no. 10; p. 1529
Main Authors Sjögren, Magnus, Huttunen, Henri J, Svenningsson, Per, Widner, Håkan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.09.2021
MDPI
Subjects
Antiparkinson Agents - therapeutic use
Biomarkers
Clinical trials
Clinical Trials as Topic
Dopamine receptors
Drug development
Genetic targets
Humans
Kinases
Medicin och hälsovetenskap
Molecular Targeted Therapy - methods
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative disorders
Oncology
Parkinson Disease - drug therapy
Parkinson Disease - genetics
Parkinson's disease
Precision medicine
Precision Medicine - methods
Review
precision medicine
clinical trials
genetic targets
neurodegenerative disorders
Parkinson’s disease
oncology
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Abstract Clinical trials in neurodegenerative disorders have been associated with high rate of failures, while in oncology, the implementation of precision medicine and focus on genetically defined subtypes of disease and targets for drug development have seen an unprecedented success. With more than 20 genes associated with Parkinson's disease (PD), most of which are highly penetrant and often cause early onset or atypical signs and symptoms, and an increasing understanding of the associated pathophysiology culminating in dopaminergic neurodegeneration, applying the technologies and designs into the field of neurodegeneration seems a logical step. This review describes some of the methods used in oncology clinical trials and some attempts in Parkinson's disease and the potential of further implementing genetics, biomarkers and smart clinical trial designs in this disease area.
AbstractList Clinical trials in neurodegenerative disorders have been associated with high rate of failures, while in oncology, the implementation of precision medicine and focus on genetically defined subtypes of disease and targets for drug development have seen an unprecedented success. With more than 20 genes associated with Parkinson's disease (PD), most of which are highly penetrant and often cause early onset or atypical signs and symptoms, and an increasing understanding of the associated pathophysiology culminating in dopaminergic neurodegeneration, applying the technologies and designs into the field of neurodegeneration seems a logical step. This review describes some of the methods used in oncology clinical trials and some attempts in Parkinson’s disease and the potential of further implementing genetics, biomarkers and smart clinical trial designs in this disease area.
Author Sjögren, Magnus
Svenningsson, Per
Widner, Håkan
Huttunen, Henri J
AuthorAffiliation 3 Department of Neurology, Karolinska University Hospital, 171 77 Stockholm, Sweden; per.svenningsson@ki.se
2 Department Health Sciences, Umeå University, 907 36 Umeå, Sweden
4 Department of Neurology, Lund University Hospital, 221 00 Lund, Sweden; hakan.widner@med.lu.se
1 Herantis Pharma Plc, Bertel Jungin Aukio 1, 02600 Espoo, Finland; henri.huttunen@herantis.com
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– name: 3 Department of Neurology, Karolinska University Hospital, 171 77 Stockholm, Sweden; per.svenningsson@ki.se
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crossref_primary_10_3233_JPD_230376
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Keywords precision medicine
clinical trials
genetic targets
neurodegenerative disorders
Parkinson’s disease
oncology
Language English
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  doi: 10.1038/s41531-019-0103-7
  contributor:
    fullname: Fanning
– volume: 32
  start-page: S112
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  article-title: The Multiphase Optimization Strategy (MOST) and the Sequential Multiple Assignment Randomized Trial (SMART): New Methods for More Potent eHealth Interventions
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Snippet Clinical trials in neurodegenerative disorders have been associated with high rate of failures, while in oncology, the implementation of precision medicine and...
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SubjectTerms Antiparkinson Agents - therapeutic use
Biomarkers
Clinical trials
Clinical Trials as Topic
Dopamine receptors
Drug development
Genetic targets
Humans
Kinases
Medicin och hälsovetenskap
Molecular Targeted Therapy - methods
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative disorders
Oncology
Parkinson Disease - drug therapy
Parkinson Disease - genetics
Parkinson's disease
Precision medicine
Precision Medicine - methods
Review
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Title Genetically Targeted Clinical Trials in Parkinson's Disease: Learning from the Successes Made in Oncology
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